Novel urinary biomarkers for the detection of bladder cancer: A systematic review

原文： 2018 年发布于 BMJ Open 73 卷第 3 期 81204-81214  浏览量：195次

作者： Tan W. S. Tan W. P. Tan M. Y. Khetrapal P. Dong L. deWinter P. Feber A. Kelly J. D.

作者单位： Division of Pediatric Urology, Children's National Health System, 111 Michigan Ave, NW, Washington, DC, 20010, USA. cbayne3@childrensnational.org. School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA. Department of Research/Division of Urology and Nephrology, Connecticut Children's Medical Center, Hartford, CT, USA. Division of Pediatric Urology, Children's National Health System, 111 Michigan Ave, NW, Washington, DC, 20010, USA. Biomedical Research Institute, Rockville, MD, USA. Departments of Urology and Pediatrics, The George Washington University, Washington, DC, USA.

归属分类：膀胱肿瘤治疗及预后证据

DOI： 10.1016/j.ijrobp.2019.06.1949

关键词： Asian People/*statistics & numerical data Case-Control Studies Cohort Studies Confounding Factors Epidemiologic Epidemiologic Studies Humans Japan/epidemiology Research Design Risk Factors Smoking/*adverse effects/*epidemiology Smoking Cessation Urinary Bladder Neoplasms/*epidemiology/etiology Japanese bladder cancer cigarette smoking epidemiology systematic review

AIMS: We aimed to assess the diagnostic accuracy of F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for preoperative lymph node (LN) staging in newly diagnosed bladder cancer (BC) patients through a systematic review and meta-analysis. PATIENTS AND METHODS: MEDLINE, Embase, and the Cochrane Library database, from the earliest available date of indexing through June 30, 2017, were searched for studies evaluating the diagnostic performance of F-18 FDG PET/CT for preoperative LN staging in newly diagnosed BC. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR-), and constructed summary receiver operating characteristic curves. RESULTS: Across 14 studies (785 patients), the pooled sensitivity was 0.57 (95% CI: 0.49-0.64) and the pooled specificity was 0.92 (95% CI: 0.87-0.95). The LR syntheses gave an overall LR+ of 7.4 (95% CI: 4.4-12.3) and an LR- of 0.47 (95% CI: 0.39-0.56). The pooled diagnostic odds ratio was 16 (95% CI: 9-28). CONCLUSIONS: F-18 FDG PET/CT shows a low sensitivity and high specificity for the detection of metastatic LNs in patients with newly diagnosed BC.