首页膀胱肿瘤治疗及预后证据详情

Mortality prediction models after radical cystectomy for bladder tumour: A systematic review and critical appraisal

原文: 2022 年 发布于 Eur J Clin Nutr 94 卷 第 3 期 752-760 浏览量:199次

作者: Sarrió-Sanz P. Martinez-Cayuelas L. Lumbreras B. Sánchez-Caballero L. Palazón-Bru A. Gil-Guillén V. F. Gómez-Pérez L.

作者单位: Department of Radiation Oncology, National University Cancer Institute, Singapore National University Hospital, Singapore. Department of Radiation Oncology, National Cancer Centre, Singapore.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.3390/cancers14030694

关键词: Administration Intravesical BCG Vaccine/therapeutic use Humans Neoplasm Recurrence Local/prevention & control Network Meta-Analysis *Urinary Bladder Neoplasms/drug therapy/pathology Bladder cancer Intermediate risk Intravesical therapy Non–muscle-invasive bladder cancer

文献简介

Aims: Immune checkpoint inhibitors (ICIs) have recently revolutionized the treatment landscape of metastatic urothelial carcinoma. The authors performed a meta-analysis aiming to evaluate the predictive value of Eastern Cooperative Oncology Group performance status, age, sex, liver metastasis and histology in trials comparing first-line ICI-based combinations with chemotherapy in metastatic urothelial carcinoma patients. Methods: Hazard ratios were analyzed. Results: ICI-based combinations significantly decreased the risk of death in several clinicopathological subgroups, including patients with no liver metastases (hazard ratio: 0.84; 95% CI: 0.74-0.95) and those with an Eastern Cooperative Oncology Group performance status of 0 (hazard ratio: 0.84; 95% CI: 0.72-0.97). Conclusion: The benefit of ICI-based combinations over chemotherapy in metastatic urothelial carcinoma was consistent across several clinicopathological subgroups, although a proportion of patients responded to chemotherapy alone.

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