Cystectomy/*methods Humans Organ Sparing Treatments/*methods Treatment Outcome Urinary Bladder Neoplasms/*surgery Bladder preservation High-grade non-muscle-invasive bladder cancer Meta-analysis Radical cystectomy PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Female *Health Status Humans Male Middle Aged *Quality of Life Surveys and Questionnaires Treatment Outcome Urinary Bladder/*surgery Urinary Bladder Neoplasms/*surgery Urinary Diversion/*methods Urinary Reservoirs Continent Bladder cancer Meta-analysis Quality of life Urinary diversion

*Cystectomy *Health Status Humans Patient Education as Topic/*methods Preoperative Care/*methods Relaxation Therapy/*methods Urinary Bladder Neoplasms/*surgery Bladder cancer Cystectomy Supportive intervention Systematic review PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Cystectomy/*methods Humans *Robotic Surgical Procedures Treatment Outcome Urinary Bladder Neoplasms/*surgery Oncologic outcome Open radical cystectomy Positive surgical margin Robot-assisted radical cystectomy

Cystectomy Humans Procedures and Techniques Utilization/*statistics & numerical data Prospective Studies Retrospective Studies Risk Assessment Urinary Bladder Neoplasms/*surgery Predictors Radical cystectomy Use Utilization interest including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg employment/affiliation grants or funding consultancies honoraria stock ownership or options expert testimony royalties or patents filed received or pending) are the following: None.

Blood Loss Surgical *Cystectomy Diet Humans Lymph Nodes/pathology *Minimally Invasive Surgical Procedures Postoperative Complications/etiology Randomized Controlled Trials as Topic Recurrence Treatment Outcome Urinary Bladder Neoplasms/*surgery Open radical cystectomy laparoscopic radical cystectomy meta-analysis minimally invasive randomized controlled trials robot-assisted radical cystectomy

*Conversion to Open Surgery *Cystectomy Humans Odds Ratio Operative Time Postoperative Complications/etiology *Robotic Surgical Procedures Treatment Outcome Urinary Bladder Neoplasms/*surgery complications meta-analysis open radical cystectomy robotic

Administration Intravesical Antineoplastic Agents/*administration & dosage/adverse effects Disease-Free Survival Humans Saline Solution/*administration & dosage/adverse effects *Therapeutic Irrigation/adverse effects Urinary Bladder Neoplasms/*surgery Water/*administration & dosage/adverse effects

Cystectomy/*methods Humans Robotic Surgical Procedures/*methods Urinary Bladder Neoplasms/*surgery

Carcinoma Transitional Cell/epidemiology/*surgery *Cystectomy Humans Kidney Neoplasms/*epidemiology Neoplasms Second Primary/*epidemiology Ureteral Neoplasms/*epidemiology Urethral Neoplasms/*epidemiology Urinary Bladder Neoplasms/*surgery Bladder cancer Radical cystectomy Recurrence Remnant Upper urinary tract Urethra Urothelium including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg employment/affiliation grants or funding consultancies honoraria stock ownership or options expert testimony royalties or patents filed received or pending) are the following: None.

Adenocarcinoma/epidemiology/*pathology/surgery Cystectomy/*methods Digital Rectal Examination Humans Incidental Findings Male Neoplasm Recurrence Local/pathology Prognosis Prostate/pathology Prostate-Specific Antigen Prostatectomy/*methods Prostatic Neoplasms/epidemiology/*pathology/surgery Survival Rate Urinary Bladder Neoplasms/*surgery bladder neoplasms cystectomy prostatectomy prostatic neoplasms

Cystectomy/*methods Humans Length of Stay Operative Time Postoperative Complications Robotic Surgical Procedures/*methods Treatment Outcome Urinary Bladder Neoplasms/*surgery bladder cancer cystectomy robotics

Cystectomy/*adverse effects Diurnal Enuresis/etiology Female Humans Nocturnal Enuresis/etiology *Quality of Life Sexual Dysfunction Physiological/*etiology/physiopathology Urinary Bladder Neoplasms/*surgery Urinary Diversion/adverse effects Urinary Incontinence/*etiology Cystectomy Functional outcomes Gender disparities Outcomes assessment Urinary bladder neoplasms

Anemia/*complications Cystectomy/*methods Female Humans Male Preoperative Period Proportional Hazards Models Survival Analysis Treatment Outcome Urinary Bladder Neoplasms/*surgery Anemia Bladder cancer Hemoglobin Mortality Recurrence

Cystectomy/*methods Feasibility Studies Humans Treatment Outcome Urethra Urinary Bladder Neoplasms/*surgery

Cystectomy/*methods Humans Prognosis *Quality of Life Urinary Bladder Neoplasms/*surgery Bladder cancer Continent urinary diversion Incontinent urinary diversion Quality of life Radical cystectomy

Humans Treatment Outcome Urinary Bladder Neoplasms/*surgery *Urinary Diversion *Urinary Reservoirs Continent

Critical Pathways Cystectomy/*methods/rehabilitation Humans Length of Stay Postoperative Care/*methods Postoperative Complications/*epidemiology *Standard of Care Urinary Bladder Neoplasms/*surgery Urinary Diversion/*methods/rehabilitation Clinical pathways Collaborative care Cystectomy Enhanced recovery Fast track including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg employment/affiliation grants or funding consultancies honoraria stock ownership or options expert testimony royalties or patents filed received or pending) are the following: None.

*Cystectomy Humans *Quality of Life Treatment Outcome Urinary Bladder Neoplasms/*surgery *Urinary Diversion *Urinary Reservoirs Continent