Cardiovascular Diseases/*etiology Cohort Studies Humans Hypoglycemic Agents/*adverse effects/pharmacology Non-alcoholic Fatty Liver Disease/*etiology/pathology Pioglitazone Prevalence Risk Thiazolidinediones/*adverse effects/pharmacology Urinary Bladder Neoplasms/epidemiology/*etiology/pathology Bladder cancer Cardiovascular disease Non-alcoholic steatohepatitis

Asian People/genetics Biomarkers Tumor/*blood/urine Cystoscopy/adverse effects Humans MicroRNAs/*blood Neoplasm Staging Nuclear Proteins/urine Odds Ratio ROC Curve Regression Analysis Sensitivity and Specificity Urinalysis/methods Urinary Bladder Neoplasms/*blood/diagnosis/*genetics/urine Bladder cancer Diagnosis Meta-analysis miRNA authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

膀胱肿瘤 光动力诊断 白光成像 Meta分析

Bladder cancer gene genetic susceptibility genetic variant metaanalysis pathway

Carcinoma Transitional Cell/pathology/*surgery Cystectomy/*methods Humans Kaplan-Meier Estimate Neoplasm Recurrence Local Risk Factors Urethra/*pathology Urinary Bladder/pathology/surgery Urinary Bladder Neoplasms/pathology/*surgery Bladder cancer Neobladder Radical cystectomy Urethral recurrence Urothelial carcinoma

Adjuvants Immunologic/administration & dosage Administration Intravesical Antineoplastic Agents/therapeutic use BCG Vaccine/*administration & dosage Bayes Theorem Disease Progression Humans Immunotherapy/*methods Incidence Neoplasm Recurrence Local/drug therapy Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/*drug therapy Intravesical bacillus Calmette–Guerin efficacy maintenance non-muscle-invasive bladder cancer side effects

膀胱癌根治术 盆腔淋巴结清扫术 淋巴结阳性 淋巴结清扫数量 meta分析 预后

Administration Intravesical Aged Aged 80 and over Antineoplastic Combined Chemotherapy Protocols/*administration & dosage/adverse effects BCG Vaccine/administration & dosage Bayes Theorem Deoxycytidine/administration & dosage/analogs & derivatives Disease Progression Epirubicin/administration & dosage Female Humans Isoniazid/administration & dosage Male Middle Aged Mitomycin/administration & dosage Neoplasm Invasiveness Neoplasm Recurrence Local Odds Ratio Randomized Controlled Trials as Topic Risk Factors Time Factors Treatment Outcome Urinary Bladder Neoplasms/*drug therapy/mortality/pathology Gemcitabine efficacy and safety intravesical therapy non-muscle invasive bladder cancer tumor progression tumor recurrence

肌层浸润性膀胱癌 保留膀胱手术 化疗 膀胱切除术 荟萃分析

Humans Lymph Node Excision Lymph Nodes/*pathology Lymphatic Metastasis/pathology Prognosis Urinary Bladder Neoplasms/diagnosis/*pathology/*therapy

Cystectomy/*methods Humans Prognosis *Quality of Life Urinary Bladder Neoplasms/*surgery Bladder cancer Continent urinary diversion Incontinent urinary diversion Quality of life Radical cystectomy

Case-Control Studies Catechol O-Methyltransferase/*genetics Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Kidney Neoplasms/enzymology/*genetics Male Polymorphism Single Nucleotide Prostatic Neoplasms/enzymology/*genetics Risk Factors Urinary Bladder Neoplasms/enzymology/*genetics

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Chemotherapy Adjuvant Cisplatin/administration & dosage *Cystectomy/methods Evidence-Based Medicine Humans *Lymph Node Excision Neoadjuvant Therapy/*methods Neoplasm Invasiveness Organ Sparing Treatments/methods Randomized Controlled Trials as Topic Survival Analysis Treatment Outcome Urinary Bladder Neoplasms/mortality/*pathology/*therapy adjuvant chemotherapy bladder cancer bladder-sparing therapy lymph node dissection neoadjuvant chemotherapy radical cystectomy

*Cytodiagnosis Female Humans Male Predictive Value of Tests Urinary Bladder Neoplasms/pathology/*urine

Diet Exercise Female Humans Male Meta-Analysis as Topic Occupational Exposure/adverse effects Occupations Risk Factors Smoking/adverse effects Urinary Bladder Neoplasms/*etiology/prevention & control Bladder cancer Lifestyle Obesity Occupation Prevention Smoking

Aminolevulinate and transurethral resection bladder cancer fluorescence hexaminolevulinate photodynamic diagnosis progression

Adult Aged Aged 80 and over Antibodies Monoclonal/therapeutic use Antibodies Monoclonal Humanized/therapeutic use B7-H1 Antigen/*antagonists & inhibitors/genetics CTLA-4 Antigen/*antagonists & inhibitors/genetics Clinical Trials as Topic Female Genes cdc/drug effects Humans Ipilimumab Male Middle Aged Neoplasm Metastasis/*drug therapy/genetics/pathology Nivolumab Urinary Bladder Neoplasms/*drug therapy/genetics/pathology Bladder cancer immunotherapy Checkpoint inhibitor Pembrolizumab

*Health Status Humans *Life Style *Quality of Life Survivors/*psychology Urinary Bladder Neoplasms/*psychology/therapy Bladder cancer Diet Exercise Lifestyle factors Quality of life Smoking Urothelial carcinoma