5-ala 5-aminolaevulinic acid Hal Pdd accuracy meta-analysis bladder cancer blue light cystoscopy cystoscopy hexaminolevulinate narrow band imaging photodynamic diagnosis fluorescence consultant for Janssen Ferring Photocure Taris Spectrum Pacific Edge QED Abbvie Johnson & Johnson Seattle Genetics Nucleix Aduro and BMS. Ashish Kamat is is a consultant for Photocure. Mihir Desai is a consultant for Procept Biorobotics and Auris Surgical. Yair Lotan is a consultant for Photocure. Angela Smith is an investigator for Urogen and a consultant for FerGene Urogen and Merck.

Blood Loss Surgical/statistics & numerical data Cystectomy/*methods Humans Length of Stay/statistics & numerical data Lymph Node Excision *Minimally Invasive Surgical Procedures Operative Time Postoperative Complications/epidemiology Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/*surgery Bladder cancer Meta-analysis Minimally invasive Open radical cystectomy Randomized controlled trials

5 alpha reductase inhibitors androgen deprivation therapy androgen receptor bladder cancer

Adult Aged Aged 80 and over Female Humans Male Middle Aged Urinary Bladder Neoplasms/*radiotherapy Bladder neoplasm Bladder preservation Cis Chemoradiotherapy Radiotherapy T1 Bladder cancer

Androgen Antagonists/*therapeutic use Humans Male Observational Studies as Topic Prostatic Neoplasms/*drug therapy Risk Assessment Urinary Bladder Neoplasms/epidemiology/*prevention & control Androgen deprivation therapy Bladder cancer Pharmacoepidemiology Prostate cancer Systematic review

Adult Aged Aged 80 and over Female *Health Services Needs and Demand Humans Male Middle Aged Sexual Dysfunction Physiological/*etiology *Sexual Health Urinary Bladder Neoplasms/*complications/*therapy Bladder cancer Health-related quality of life Mental wellbeing Radical cystectomy Sexual health

Biomarkers/urine DNA Mutational Analysis DNA Neoplasm/*urine Disease Progression Humans Mutation Neoplasm Recurrence Local/*diagnosis/genetics/*urine Sensitivity and Specificity Urinary Bladder Neoplasms/*diagnosis/genetics/*urine #BladderCancer #blcsm biomarkers molecular diagnostics urinary bladder neoplasms urine analysis Amsterdam UMC location VUmc. J. Bosschieter R.D.M. Steenbergen and J.A. Nieuwenhuijzen are inventors on patent(s) related to the work.

Aged Carcinoma Transitional Cell/*surgery *Cystectomy/methods Female Humans *Lymph Node Excision Male Middle Aged Postoperative Complications Randomized Controlled Trials as Topic Treatment Outcome Urinary Bladder Neoplasms/*surgery

Anesthetics Local/*therapeutic use *Cystoscopy Humans Lidocaine/*therapeutic use Male Pain Management/*methods Pain Measurement Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/diagnosis/therapy administration cystoscopy intravesical lidocaine pain procedural urinary bladder neoplasms

Humans Patient Outcome Assessment *Patient Reported Outcome Measures Quality of Life Randomized Controlled Trials as Topic Reproducibility of Results Urinary Bladder Neoplasms/*diagnosis/pathology/psychology/*therapy Early bladder cancer Non-muscle invasive bladder cancer Patient-reported outcome measures Systematic review

diagnosis meta-analysis urinary bladder urine biomarkers urothelial carcinoma BioScience Corp. Norihiko Masuda Osamu Ogawa Meyeon Park Alvin Y Liu Yunfeng Dai Landon Kozai Hideki Furuya Yair Lotan and Takashi Kobayashi declare that they have no conflicts of interest.

Cystectomy/*methods Humans Postoperative Complications/epidemiology Quality of Life Randomized Controlled Trials as Topic Robotic Surgical Procedures/*methods Treatment Outcome Urinary Bladder Neoplasms/*surgery

Cystectomy/*methods Humans *Quality of Life Randomized Controlled Trials as Topic Treatment Outcome Urinary Bladder Neoplasms/*surgery *Urinary Diversion/methods *Urinary Reservoirs Continent Bladder cancer index Bricker Cystectomie radicale Ileal conduit Meta-analysis Méta-analyse Néovessie de substitution Orthotopic neobladder Quality of life Qualité de vie Radical cystectomy Revue systématique Systematic review

Cystectomy/adverse effects/*methods Humans *Minimally Invasive Surgical Procedures Perioperative Period Postoperative Complications Randomized Controlled Trials as Topic *Robotic Surgical Procedures/adverse effects Urinary Bladder Neoplasms/*surgery Bladder cancer Meta-analysis Radical cystectomy Randomized controlled trial Robot-assisted radical cystectomy

Adult Aged Aged 80 and over Cystectomy/methods/mortality Female Humans Hydronephrosis/*physiopathology/surgery Male Middle Aged Neoplasm Staging Prognosis Proportional Hazards Models Retrospective Studies Urinary Bladder/pathology Urinary Bladder Neoplasms/*complications/*pathology

Cystectomy/*methods Humans Perioperative Care/*methods Postoperative Complications/epidemiology/prevention & control *Recovery of Function Standard of Care Urinary Bladder Neoplasms/*surgery Urologic Surgical Procedures/*methods

Adjuvants Immunologic/administration & dosage Administration Intravesical BCG Vaccine/*adverse effects Chondroitin Sulfates/*administration & dosage Cystitis/chemically induced/pathology/*prevention & control Humans Hyaluronic Acid/*administration & dosage Immunotherapy/*adverse effects Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/pathology/*therapy

Carcinoma Transitional Cell/*diagnostic imaging/pathology/surgery Cystectomy Humans Lymph Nodes/*diagnostic imaging/pathology Lymphatic Metastasis/diagnostic imaging Magnetic Resonance Imaging Neoplasm Staging Positron Emission Tomography Computed Tomography Sensitivity and Specificity Tomography X-Ray Computed Urinary Bladder Neoplasms/*diagnostic imaging/pathology/surgery Bladder cancer Computed tomography Positron emission tomography Transitional cell carcinoma

Biological Assay/methods Biomarkers Tumor/*urine Cystoscopy Humans Sensitivity and Specificity Urinary Bladder Neoplasms/diagnosis/*urine

Cystectomy/methods/*mortality Humans Lymph Node Excision/methods/*mortality Lymph Nodes/surgery Lymphatic Metastasis Pelvis/pathology Postoperative Complications/etiology Prognosis Randomized Controlled Trials as Topic Survival Rate Treatment Outcome Urinary Bladder Neoplasms/*mortality/pathology/*surgery