Bayes Theorem Cystectomy Humans *Laparoscopy Postoperative Complications/surgery *Robotic Surgical Procedures *Robotics Treatment Outcome *Urinary Bladder Neoplasms/surgery

Cystectomy/methods Humans Quality of Life *Urinary Bladder Neoplasms/surgery *Urinary Diversion/methods *Urinary Reservoirs Continent nursing systematic review urinary diversion

Humans Female Male Infant *Urinary Bladder Neoplasms/diagnosis/therapy/pathology *Carcinoma Transitional Cell/pathology Urinary Bladder/pathology Neoplasm Staging Cystoscopy Cystectomy/methods

Bladder cancer neoadjuvant chemotherapy radical cystectomy systematic review variant histology urothelial cancer

Cystectomy/*methods Electrosurgery/*methods Humans Neoplasm Invasiveness Urethra Urinary Bladder Neoplasms/pathology/*surgery Bipolar Meta-analysis Monopolar Non-muscle invasive bladder cancer Transurethral resection

*Cystectomy Humans *Neoadjuvant Therapy Neoplasm Staging Treatment Outcome Urinary Bladder Neoplasms/*drug therapy/pathology/*surgery

*Cystectomy/adverse effects Humans Postoperative Complications/epidemiology/etiology Prospective Studies Retrospective Studies *Robotic Surgical Procedures/adverse effects *Robotics Treatment Outcome *Urinary Bladder Neoplasms/surgery Bladder cancer Intracorporeal Meta-analysis Radical cystectomy Robot-assisted

Cystectomy/adverse effects Female Humans Male Network Meta-Analysis *Urinary Bladder Neoplasms/pathology/surgery Urologic Surgical Procedures Tueb Turbt bladder cancer en bloc transurethral en bloc transurethral resection

*Cystectomy Humans Prospective Studies Systematic Reviews as Topic Treatment Outcome Urinary Bladder/pathology/surgery *Urinary Bladder Neoplasms/pathology/surgery models mortality nomograms radical cystectomy urinary bladder neoplasms

adjuvant chemotherapy bladder cancer cystectomy

Apoptosis B7-H1 Antigen/genetics/metabolism *Carcinoma Transitional Cell/pathology Cystectomy Humans Immune Checkpoint Inhibitors Ligands Lymph Node Excision Neoplasm Recurrence Local/pathology Prognosis Programmed Cell Death 1 Receptor Urinary Bladder *Urinary Bladder Neoplasms/pathology bladder urothelial carcinoma meta-analysis prognostic value programmed cell death ligand-1 radical cystectomy commercial or financial relationships that could be construed as a potential conflict of interest.

Antineoplastic Combined Chemotherapy Protocols/therapeutic use *Carcinoma Transitional Cell/pathology Cisplatin/therapeutic use Cystectomy Humans Muscles/pathology Neoadjuvant Therapy Neoplasm Invasiveness *Urinary Bladder Neoplasms/pathology Bladder cancer Muscle-invasive Urothelial from MSD and BMS and Speaker and Other from AstraZecena. BPV reports Advisory Board Speaker and Other from Astellas Roche BMS and Merk-Pfizer Advisory Board and Other from Ipsen Advisory Board and Speaker from EUSA and MSD and Advisory Board from Sanofi. IPF report Advisory Board Speaker and Other from Pfizer Speaker and Other from Ipsen and Roche Advisory Board from EUSA and BMS and Speaker from Novartis and MSD. OFC reports Advisory Board and Speaker from Ipsen and Astellas Advisory Board from BMS and Pfizer-Merck and Speaker from AstraZeneca. AGA has received research funding from Astellas travel grants from Astellas Jansen Sanofi BMS Roche Pfizer and Ipsen and honoraria for speaker engagements advisory boards and continuous medical education from Janssen Astellas Sanofi Bayer Roche Ipsen BMS MSD Pfizer Eusa Pharma Eisai and AstraZeneca. JAA reports honoraria from Astellas Pfizer and BMS conulting or advisory role from Pfizer Astellas Janssen-Cilag MSD Oncology BMS Merck AstraZeneca Bayer and Eisai and Research Funding from BMS. RMB SVE CCD and MDS have nothing to disclose.

Cystectomy France Humans Lymphatic Irradiation Palliative Care Patient Positioning Radiation Oncology Radiotherapy Dosage Radiotherapy Adjuvant Radiotherapy Conformal Urinary Bladder Neoplasms/diagnostic imaging/pathology/*radiotherapy/surgery Bladder cancer Cancers de la vessie Chemoradiation Chimioradiothérapie French society for radiation oncology Guidelines Radiation therapy Radiothérapie Recommandations Société française de radiothérapie oncologique

Cystectomy/*methods Humans *Margins of Excision Survival Rate Ureter/*surgery Urinary Bladder Neoplasms/mortality/*surgery Bladder cancer Cancer de vessie Cystectomie Cystectomy Examen extemporané Frozen section Recoupes urétérales Ureteral margin

Radical cystectomy bladder preservation distant metastasis rate (DMR) muscular invasive bladder cancer (MIBC) survival rate form (available at https://dx.doi.org/10.21037/tau-21-564). The authors have no conflicts of interest to declare.

Humans *Urinary Bladder Neoplasms/diagnosis/therapy/pathology BCG Vaccine/therapeutic use Cystectomy Administration Intravesical Urinary Bladder/pathology Bcg Bladder Bladder tumours Cancer Carcinome urothélial Cystectomie Cytologie urinaire Survie Survival Tumeurs de la vessie Urine cytology Urothelial carcinoma Vessie

Humans *Cystectomy/methods *Urinary Bladder Neoplasms/radiotherapy/surgery Urinary Bladder Radiotherapy Adjuvant/methods Prospective Studies Margins of Excision

Cystectomy/methods Humans Learning Curve Postoperative Complications/etiology/surgery *Robotic Surgical Procedures/methods *Robotics Treatment Outcome *Urinary Bladder Neoplasms/surgery bladder cancer cystectomy systematic review

Aged Cystectomy/adverse effects Humans Quality of Life Ureterostomy *Urinary Bladder Neoplasms/surgery *Urinary Diversion/adverse effects Cystectomy Systematic Review [Publication Type] Urinary Bladder Neoplasms

Blood Loss Surgical/statistics & numerical data Blood Transfusion/statistics & numerical data Cystectomy/*methods Female Humans Male Neoplasm Invasiveness Postoperative Complications/epidemiology/etiology Robotic Surgical Procedures/*methods Treatment Outcome Urinary Bladder Neoplasms/pathology/*surgery Urinary Diversion/adverse effects/*methods Ecud Extracorporeal urinary diversion Icud Intracorporeal urinary diversion Rarc