Adjuvant Chemotherapy Bladder-sparing Chemoradiation Enhanced Recovery after Surgery Muscle-invasive Bladder Cancer Neoadjuvant Chemotherapy Radical Cystectomy Transurethral Resection of Bladder Tumor Trimodal Urothelial Carcinoma of Bladder Variant Histology

Humans *Transurethral Resection of Bladder Neoplasm Recurrence Local/pathology *Urinary Bladder Neoplasms/diagnosis/surgery/pathology Prognosis Urologic Surgical Procedures Cystectomy Bladder cancer Css Os Pfs Rfs Transurethral resection of bladder tumors financial ties to disclose.

Humans Cystectomy/adverse effects/methods *Urinary Bladder Neoplasms/surgery/etiology Urinary Bladder *Urinary Diversion/adverse effects/methods *Acidosis/epidemiology/etiology/therapy Acidosis metabólica Bicarbonate Bicarbonato Bladder tumor Cistectomía radical Derivación urinaria Metabolic acidosis Radical cystectomy Tratamiento Treatment Tumor vesical Urinary diversion

Humans *Urinary Bladder Neoplasms/surgery/pathology Urologic Surgical Procedures Cystectomy *Laser Therapy *Lasers Solid-State/therapeutic use Turbt bladder tumor laser resection recurrence

detrusor muscle en bloc resection of bladder tumor non-muscle invasive bladder cancer

Humans *Obturator Nerve/physiology/surgery Network Meta-Analysis Transurethral Resection of Bladder *Urinary Bladder Neoplasms/surgery/pathology Reflex bladder cancer lumbar anesthesia obturator nerve block transurethral resection of bladder tumor conflicts of interest to declare.

Humans *Urinary Bladder Neoplasms/surgery/pathology Lasers Urethra/surgery Treatment Outcome Length of Stay 2-micron laser bladder cancer meta-analysis randomized controlled trials trans-urethral resection of bladder tumor

Biomarkers Tumor *Carcinoma Transitional Cell/diagnosis Female Humans Male Nuclear Proteins Sensitivity and Specificity *Urinary Bladder Neoplasms/diagnosis/pathology bladder tumor diagnosis meta analysis nuclear matrix protein urine cytology

Cystectomy/*methods Electrosurgery/*methods Humans Neoplasm Invasiveness Treatment Outcome Urethra Urinary Bladder Neoplasms/pathology/*surgery Bipolar Meta-analysis Monopolar Transurethral bladder tumor resection

Cystectomy/adverse effects/*methods Disease-Free Survival Follow-Up Studies Humans Incidence Intraoperative Complications/*epidemiology/etiology Length of Stay/statistics & numerical data Neoplasm Recurrence Local/*epidemiology/etiology/prevention & control Randomized Controlled Trials as Topic Urinary Bladder/*injuries/pathology/surgery Urinary Bladder Neoplasms/mortality/pathology/*surgery Bipolar bladder tumors meta-analysis monopolar transurethral resection

Cystectomy/*methods Humans Neoplasm Invasiveness Urethra Urinary Bladder Neoplasms/pathology/*surgery Bladder tumor En bloc resection Meta-analysis Transurethral resection

Administration Intravesical Antineoplastic Agents/administration & dosage Combined Modality Therapy Cystectomy/methods Humans Randomized Controlled Trials as Topic Saline Solution/*administration & dosage/adverse effects Therapeutic Irrigation/adverse effects/methods Treatment Outcome Urethra Urinary Bladder Neoplasms/drug therapy/surgery/*therapy Continuous saline bladder irrigation Meta-analysis Non-muscle invasive bladder cancer Randomized controlled trials Transurethral resection of bladder tumors

bladder tumor childhood exposure environmental smoking nonsmoking adult

Adjuvants Immunologic/*therapeutic use Administration Intravesical BCG Vaccine/*therapeutic use Carcinoma Transitional Cell/pathology/*therapy Cystoscopy Female Humans Male Multivariate Analysis Muscle Smooth/*pathology Neoplasm Invasiveness Neoplasm Recurrence Local/*epidemiology Proportional Hazards Models Sex Factors Survival Rate Urinary Bladder Neoplasms/pathology/*therapy *Urologic Surgical Procedures Bladder cancer Gender differences Local recurrence Meta-analysis Transurethral resection of bladder tumor

Aged Catheterization Chemotherapy Adjuvant Feasibility Studies Female Humans *Laser Therapy Length of Stay Male Middle Aged Operative Time Postoperative Complications/etiology Time Factors Treatment Outcome Urinary Bladder Neoplasms/drug therapy/pathology/*radiotherapy/*surgery Bladder tumor Laser enucleation of bladder tumor Meta-analysis Transurethral resection of bladder tumor (TURBT)