首页膀胱肿瘤治疗及预后证据详情

加速康复外科理念应用于腹腔镜膀胱癌根治术中临床疗效的 meta 分析

原文: 2019 年 发布于 Clin Exp Med 2 卷 第 3 期 3781-3791 浏览量:218次

作者: 俞燕华

作者单位: Department of Urology, University Medical Centre Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. frederik.wessels@umm.de. Department of Urology, University Medical Centre Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. Library for the Medical Faculty, Mannheim of Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68165, Mannheim, Germany. Department of Anesthesiology and Critical Care Medicine, University Medical Centre Mannheim, Theodor-Kutzer-Ufer 1-3, 68165, Mannheim, Germany. Department of Urology, Marien Hospital, Ruhr-University Bochum, Herne, Germany.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.1016/j.urolonc.2021.03.005

关键词: Radical cystectomy metastatic bladder cancer non-organ confined bladder cancer

文献简介

BACKGROUND: Epidemiologic studies that investigated alcohol consumption in relation to the risk of bladder cancer (BCa) have demonstrated inconsistent results. We conducted a systematic review and meta-analysis of the literature to investigate the association of alcohol including different types of alcoholic beverages consumption with the risk of BCa. MATERIALS AND METHODS: A systematic search of Web of Science, Medline/PubMed and Cochrane library was performed in May 2018. Studies were considered eligible if they assessed the risk of BCa due to alcohol consumption (moderate or heavy dose) and different types of alcoholic beverages (moderate or heavy dose) in multivariable analysis in the general population (all genders, males or females) or compared with a control group of individuals without BCa. STUDY DESIGN: observational cohorts or case-control. RESULTS: Sixteen studies were included in this meta-analysis. Moderate and heavy alcohol consumption did not increase the risk of BCa in the entire population. Sub-group and sensitivity analyses revealed that heavy alcohol consumption increased significantly the risk of BCa in the Japanese population, RR 1.31 (95% CI 1.08-1.58, P < 0.01) in the multivariable analysis, and in males RR of 1.50 (95% CI 1.18-1.92, P < 0.01), with no significant statistical heterogeneity. Moreover, heavy consumption of spirits drinks increased the risk of BCa in males, RR 1.42 (95% CI 1.15-1.75, P < 0.01). CONCLUSION: In this meta-analysis, moderate and heavy alcohol consumption did not increase the risk of bladder cancer significantly. However, heavy consumption of alcohol might increase the risk of BCa in males and in some specific populations.

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