首页膀胱肿瘤治疗及预后证据详情

Methotrexate, vinblastine, adriamycin, and cisplatin (MVAC) versus gemcitabine, and cisplatin (GC) as neoadjuvant chemotherapy in muscle-invasive bladder cancer, a systematic review and meta-analysis

原文: 2021 年 发布于 World Journal of Surgical Oncology 12 卷 第 10 期 572-581 浏览量:229次

作者: Benkhadra R. Nayfeh T. Patibandla N. S. K. Peterson C. Prokop L. Alhalabi O. Murad M. H. Mao S. F.

作者单位: Health Economics and Decision Science, School of Health and Related Research, The University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK. o.mandrik@sheffield.ac.uk. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Department of Oncology and Metabolism, University of Sheffield, Sheffield, S10 2RX, UK. Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, S10 2JF, UK. Health Economics and Decision Science, School of Health and Related Research, The University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.3390/ijms24065846

关键词: 高级别非肌层浸润性膀胱癌 根治性膀胱切除术 保留膀胱术 meta分析 临床疗效

文献简介

Purpose: To assess the diagnostic accuracy of fluorine-18 fluorodeoxyglucose positron emission tomography combined with the computed tomography (18F-FDG PET/CT) in the detection of recurrent or residual urinary bladder cancer with meta-analysis. Methods: We searched PubMed/MEDLINE, Embase, Web of Science, CBM, CNKI, VIP, and Wanfang databases through October 2019. Two reviewers independently screened the full articles. The imaging findings were confirmed by either histopathology or clinical follow-up. Sensitivity, specificity likelihood ratio and diagnostic odds ratio were pooled with 95 % confidence intervals (CI). Overall test performance was summarized by a summary receiver operating characteristic (ROC) curve. The Meta-DiSc software (version 1.4) was used to perform the meta-analysis. Results: The meta-analysis included 7 studies. The pooled sensitivity and specificity of PET/CT for the detection of recurrent or residual urinary bladder cancer was 94.0% (95% CI: 91.0%-96.0%) and 92.0% (95% CI: 88.0%95.0%), respectively. Positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were 9.77 (95% CI: 4.91-19.41), 0.99(95% CI: 0.06-0.13) and 95.09 (95% CI: 47.96-188.53), respectively. When residual urinary bladder cancer was excluded, sensitivity changed slightly. Conclusion: This meta-analysis suggested that the diagnostic accuracy of PET/CT was good in detecting recurrent or residual urinary bladder cancer.

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