*Body Mass Index Cohort Studies Humans Odds Ratio Prospective Studies Risk Factors Urinary Bladder Neoplasms/*epidemiology/*etiology bladder cancer body mass index dose-response meta-analysis risk

Administration Intravesical Aged Aged 80 and over BCG Vaccine/*therapeutic use Biopsy Needle Disease-Free Survival Female Humans Immunohistochemistry Immunotherapy/*methods In Situ Hybridization Fluorescence Male Middle Aged Neoplasm Recurrence Local/mortality/*pathology Predictive Value of Tests Prognosis Risk Assessment Survival Analysis Treatment Outcome Urinary Bladder Neoplasms/mortality/pathology/*therapy Bcg Bladder cancer Immunotherapy Personalized therapy Response prediction

Arylamine N-Acetyltransferase/*genetics Genotype Humans Isoenzymes/*genetics Phenotype Polymorphism Genetic Urinary Bladder Neoplasms/*enzymology/*genetics N-Acetyltransferase Nat1 genetic polymorphism meta-analysis smoking systematic review urinary bladder cancer

bladder cancer circulating tumor cells (CTCs) meta-analysis prognosis urothelial cancer

Chemoradiotherapy Adjuvant Combined Modality Therapy Cystectomy/*methods Disease-Free Survival Humans Muscles/pathology Neoadjuvant Therapy Neoplasm Invasiveness Treatment Outcome Urinary Bladder Neoplasms/pathology/*therapy Bladder cancer Radical cystectomy Trimodal therapy

Alleles Case-Control Studies *Genetic Predisposition to Disease Genotype Glutathione Transferase/*genetics Humans Odds Ratio *Polymorphism Genetic Publication Bias Risk Urinary Bladder Neoplasms/epidemiology/*genetics Gstm1 Gstt1 bladder cancer polymorphism

Adult Aged Aged 80 and over Female Humans *Magnetic Resonance Imaging Male Middle Aged *Neoplasm Staging/methods/standards Urinary Bladder Neoplasms/*diagnostic imaging bladder cancer diagnostic accuracy magnetic resonance imaging staging systematic review

Biomarkers Tumor/*urine Fibronectins/*urine Humans Prognosis Urinary Bladder Neoplasms/*diagnosis/urine Biomarker Bladder cancer Diagnosis Meta-analysis Urine fibronectin standards of institutional and international research committee this article is based on previous published studies thus it does not contain any studies with human participants or animals. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

biomarkers ‹› urine bladder cancer ‹› miRNA ‹› microRNA ‹›

Biomarkers Tumor *Cystoscopy *Cytodiagnosis Early Detection of Cancer Humans Prospective Studies Reproducibility of Results Retrospective Studies Sensitivity and Specificity Urinary Bladder Neoplasms/complications/*diagnosis/pathology Urinary Bladder Neurogenic/*complications (MeSH): neurogenic bladder bladder cancer cystoscopy screening urinary cytology

Asian People/*genetics *Genetic Predisposition to Disease Glutathione Transferase/*genetics Humans Polymorphism Single Nucleotide Urinary Bladder Neoplasms/*genetics Bladder cancer glutathione S-transferase M1 glutathione S-transferase T1 meta-analysis

Humans Neoplasm Recurrence Local/*diagnosis Obesity/complications/*diagnosis Risk Factors Urinary Bladder Neoplasms/*diagnosis Bladder cancer Obesity Recurrence Survival

Bladder cancer Hazard ratio Pioglitazone Risk ratio Type 2 diabetes

Cd147 bladder cancer clinicopathological features meta-analysis prognosis

Bladder cancer enhanced recovery fast track radical cystectomy

Chemoradiotherapy/*methods Combined Modality Therapy Cystectomy/*adverse effects/methods Disease-Free Survival Female Humans Male Middle Aged Neoplasm Metastasis Robotic Surgical Procedures/*adverse effects/methods Treatment Outcome Urinary Bladder Neoplasms/diagnostic imaging/*therapy Bladder cancer Cystectomy Multi-modality treatment Port-site metastasis Rare complications

*Acetates *Carbon Carbon Radioisotopes Carcinoma Transitional Cell/*diagnostic imaging/pathology *Choline Humans Likelihood Functions Lymph Nodes/*diagnostic imaging/pathology Lymphatic Metastasis Neoplasm Staging Odds Ratio Positron Emission Tomography Computed Tomography ROC Curve Sensitivity and Specificity Urinary Bladder Neoplasms/*diagnostic imaging/pathology Bladder cancer C-11 acetate C-11 choline Lymph node Pet/ct Staging

Bladder cancer chemotherapy neoadjuvant therapy

Cystectomy/*methods Humans Length of Stay Operative Time Postoperative Complications Robotic Surgical Procedures/*methods Treatment Outcome Urinary Bladder Neoplasms/*surgery bladder cancer cystectomy robotics

Adjuvants Immunologic/*administration & dosage Administration Intravesical Antineoplastic Agents/therapeutic use BCG Vaccine/*administration & dosage Humans Instillation Drug Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/pathology/*therapy Bacillus Calmette-Guerin Maintenance therapy Non-muscle-invasive bladder cancer Progression Recurrence