Administration Intravesical BCG Vaccine/therapeutic use Disease Progression Female Humans *Ki-67 Antigen Male *Neoplasm Invasiveness Prognosis Prospective Studies *Urinary Bladder Neoplasms/diagnosis/drug therapy/pathology Ki67 meta-analysis non-muscular-invasive bladder cancer

Anemia/*complications Cystectomy/*methods Female Humans Male Preoperative Period Proportional Hazards Models Survival Analysis Treatment Outcome Urinary Bladder Neoplasms/*surgery Anemia Bladder cancer Hemoglobin Mortality Recurrence

Administration Intravesical BCG Vaccine/administration & dosage/*therapeutic use Chemotherapy Adjuvant Dose-Response Relationship Drug Drug Administration Schedule Humans Neoplasm Recurrence Local Prospective Studies Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/*drug therapy/mortality/surgery

Diabetes Mellitus/diagnosis/*drug therapy/epidemiology Dose-Response Relationship Drug Humans Hypoglycemic Agents/*adverse effects Linear Models Multivariate Analysis Odds Ratio Pioglitazone Risk Assessment Risk Factors Thiazolidinediones/*adverse effects Time Factors Urinary Bladder Neoplasms/*chemically induced/diagnosis/epidemiology

Humans *Lymph Node Excision Lymphatic Metastasis Muscle Smooth/pathology Neoplasm Invasiveness Prognosis Urinary Bladder Neoplasms/pathology/*surgery Cáncer vesical con infiltración de la muscular Linfadenectomía Lymph node anatomical territory Lymphadenectomy Muscle invasive bladder cancer Oncological value Territorios anatómicos ganglionares Valor oncológico

Animals Cattle Diet/*adverse effects *Evidence-Based Medicine Food Preserved/*adverse effects Humans Incidence Meat/*adverse effects Meat Products/*adverse effects Reproducibility of Results Risk Factors Sheep Domestic Sus scrofa Urinary Bladder Neoplasms/epidemiology/*etiology Bladder cancer Dose–response Meta-analysis Processed meat Red meat

Acetylation Arylamine N-Acetyltransferase/*genetics/metabolism Asian People/genetics Case-Control Studies China/epidemiology Genetic Association Studies Genetic Predisposition to Disease Humans Odds Ratio Phenotype *Polymorphism Single Nucleotide Risk Assessment Risk Factors Urinary Bladder Neoplasms/enzymology/ethnology/*genetics

Clinical Decision-Making Cystectomy/*methods Cytoreduction Surgical Procedures/methods Humans *Neoplasm Metastasis/pathology/therapy Practice Guidelines as Topic Treatment Outcome *Urinary Bladder Neoplasms/pathology/surgery Bladder cancer Lymph node dissection Lymph node metastasis Metastasectomy Metastatic bladder cancer Surgery interest including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg employment/affiliation grants or funding consultancies honoraria stock ownership or options expert testimony royalties or patents filed received or pending) are the following: None.

Antioxidants/*therapeutic use Databases Factual Dietary Supplements Humans Randomized Controlled Trials as Topic Risk Urinary Bladder Neoplasms/pathology/*prevention & control Vitamins/*therapeutic use beta Carotene/therapeutic use Antioxidant Bladder Cancer Meta-Analysis Randomized Controlled Trials Vitamin

Aged Catheterization Chemotherapy Adjuvant Feasibility Studies Female Humans *Laser Therapy Length of Stay Male Middle Aged Operative Time Postoperative Complications/etiology Time Factors Treatment Outcome Urinary Bladder Neoplasms/drug therapy/pathology/*radiotherapy/*surgery Bladder tumor Laser enucleation of bladder tumor Meta-analysis Transurethral resection of bladder tumor (TURBT)

Carcinoma Transitional Cell/pathology/*surgery Cystectomy/*methods Humans Kaplan-Meier Estimate Neoplasm Recurrence Local Risk Factors Urethra/*pathology Urinary Bladder/pathology/surgery Urinary Bladder Neoplasms/pathology/*surgery Bladder cancer Neobladder Radical cystectomy Urethral recurrence Urothelial carcinoma

Age Factors Aged Aged 80 and over Clinical Decision-Making *Cystectomy/adverse effects/mortality Disease-Free Survival Female Geriatric Assessment Humans Life Expectancy Male Middle Aged Neoplasm Invasiveness Odds Ratio Patient Selection Quality of Life Radiotherapy/adverse effects/mortality Risk Factors Time Factors Treatment Outcome Urinary Bladder Neoplasms/mortality/pathology/*therapy Complications Elderly Mibc Outcome

Adjuvants Immunologic/administration & dosage Administration Intravesical Antineoplastic Agents/therapeutic use BCG Vaccine/*administration & dosage Bayes Theorem Disease Progression Humans Immunotherapy/*methods Incidence Neoplasm Recurrence Local/drug therapy Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/*drug therapy Intravesical bacillus Calmette–Guerin efficacy maintenance non-muscle-invasive bladder cancer side effects

Cystectomy/*methods Disease-Free Survival Humans Lymphatic Metastasis *Margins of Excision Neoplasm Recurrence Local Neoplasm Staging Prognosis Treatment Outcome Urinary Bladder Neoplasms/pathology/*surgery bladder cancer meta-analysis outcome radical cystectomy surgical margin status

Administration Intravesical Aged Aged 80 and over Antineoplastic Combined Chemotherapy Protocols/*administration & dosage/adverse effects BCG Vaccine/administration & dosage Bayes Theorem Deoxycytidine/administration & dosage/analogs & derivatives Disease Progression Epirubicin/administration & dosage Female Humans Isoniazid/administration & dosage Male Middle Aged Mitomycin/administration & dosage Neoplasm Invasiveness Neoplasm Recurrence Local Odds Ratio Randomized Controlled Trials as Topic Risk Factors Time Factors Treatment Outcome Urinary Bladder Neoplasms/*drug therapy/mortality/pathology Gemcitabine efficacy and safety intravesical therapy non-muscle invasive bladder cancer tumor progression tumor recurrence

Biomarkers Tumor/*genetics Epigenesis Genetic/*genetics Humans Methylation Mycobacterium bovis/*genetics Prognosis Urinary Bladder Neoplasms/*genetics/pathology/surgery

Cystectomy/*methods Feasibility Studies Humans Treatment Outcome Urethra Urinary Bladder Neoplasms/*surgery

Antineoplastic Combined Chemotherapy Protocols/therapeutic use Bayes Theorem Carcinoma Transitional Cell/*drug therapy/pathology/surgery Cisplatin/therapeutic use Cystectomy Deoxycytidine/analogs & derivatives/therapeutic use Doxorubicin/therapeutic use Humans Methotrexate/therapeutic use *Neoadjuvant Therapy Neoplasm Invasiveness/pathology Urinary Bladder Neoplasms/*drug therapy/pathology/surgery Vinblastine/therapeutic use Gemcitabine

Cystectomy/*methods Humans Lymph Node Excision Lymph Nodes/*pathology Lymphatic Metastasis/*diagnosis Urinary Bladder Neoplasms/*pathology/*surgery

Aged Blood Loss Surgical Cystectomy/*adverse effects/*methods Female Humans Length of Stay Male Middle Aged Operative Time Postoperative Complications/etiology Quality of Life Randomized Controlled Trials as Topic Robotic Surgical Procedures/*adverse effects/*methods Treatment Outcome Urinary Bladder/*surgery Urinary Bladder Neoplasms/surgery Urinary Diversion/*adverse effects/*methods