Bladder cancer blood transfusion cystectomy oncology prognostic marker urothelial carcinoma

Metabolic syndrome (MS) bladder cancer (BC) grade meta-analysis stage form (available at http://dx.doi.org/10.21037/tcr-20-3350). The authors have no conflicts of interest to declare.

Adult Aged Aged 80 and over Female *Health Services Needs and Demand Humans Male Middle Aged Sexual Dysfunction Physiological/*etiology *Sexual Health Urinary Bladder Neoplasms/*complications/*therapy Bladder cancer Health-related quality of life Mental wellbeing Radical cystectomy Sexual health

Biomarkers/urine DNA Mutational Analysis DNA Neoplasm/*urine Disease Progression Humans Mutation Neoplasm Recurrence Local/*diagnosis/genetics/*urine Sensitivity and Specificity Urinary Bladder Neoplasms/*diagnosis/genetics/*urine #BladderCancer #blcsm biomarkers molecular diagnostics urinary bladder neoplasms urine analysis Amsterdam UMC location VUmc. J. Bosschieter R.D.M. Steenbergen and J.A. Nieuwenhuijzen are inventors on patent(s) related to the work.

Coloring Agents Humans Indocyanine Green Lymph Node Excision *Lymphatic Metastasis/diagnostic imaging *Lymphography Male Pelvis *Prostatic Neoplasms/diagnostic imaging/pathology Sentinel Lymph Node Biopsy *Urinary Bladder Neoplasms/diagnostic imaging/pathology Cáncer de Próstata Ganglio centinela Linfadenectomía Lymph node dissection Prostate cáncer Sentinel lymph node Verde de Indocianina

Humans Patient Outcome Assessment *Patient Reported Outcome Measures Quality of Life Randomized Controlled Trials as Topic Reproducibility of Results Urinary Bladder Neoplasms/*diagnosis/pathology/psychology/*therapy Early bladder cancer Non-muscle invasive bladder cancer Patient-reported outcome measures Systematic review

Anxiety/therapy Cystectomy/*psychology Depression/therapy *Exercise Therapy Humans Physical Fitness Quality of Life Urinary Bladder Neoplasms/*psychology/*surgery Bladder cancer exercise psychosocial interventions radical cystectomy

Adult Aged Air Pollution/*adverse effects Carcinogens Environmental/*adverse effects Cohort Studies Environmental Exposure/*adverse effects Europe/epidemiology Female Humans Incidence Male Meta-Analysis as Topic Middle Aged Nitrogen Oxides/adverse effects Particulate Matter/adverse effects Prospective Studies Risk Factors Urinary Bladder Neoplasms/*epidemiology/etiology Air pollution Bladder cancer Environment Prevention

Humans Odds Ratio Prospective Studies *Urinary Bladder Neoplasms *Vitamin E bladder cancer meta-analysis vitamin E

bladder cancer clinicopathological parameters diagnosis long non-coding RNAs prognosis systematic review

Cystectomy/*methods Humans *Quality of Life Randomized Controlled Trials as Topic Treatment Outcome Urinary Bladder Neoplasms/*surgery *Urinary Diversion/methods *Urinary Reservoirs Continent Bladder cancer index Bricker Cystectomie radicale Ileal conduit Meta-analysis Méta-analyse Néovessie de substitution Orthotopic neobladder Quality of life Qualité de vie Radical cystectomy Revue systématique Systematic review

Cystectomy/adverse effects/*methods Humans *Minimally Invasive Surgical Procedures Perioperative Period Postoperative Complications Randomized Controlled Trials as Topic *Robotic Surgical Procedures/adverse effects Urinary Bladder Neoplasms/*surgery Bladder cancer Meta-analysis Radical cystectomy Randomized controlled trial Robot-assisted radical cystectomy

Antibodies Monoclonal/adverse effects/therapeutic use Antibodies Monoclonal Humanized/adverse effects/therapeutic use Antineoplastic Agents Immunological/*therapeutic use B7-H1 Antigen/*antagonists & inhibitors Clinical Trials Phase III as Topic Humans Network Meta-Analysis Programmed Cell Death 1 Receptor/*antagonists & inhibitors Salvage Therapy/*methods Survival Analysis Treatment Outcome Urinary Bladder Neoplasms/*drug therapy/*secondary PD-1 inhibitor PDL-1 inhibitor atezolizumab pembrolizumab urothelial bladder cancer

Carcinoma Papillary/mortality/pathology/*therapy Disease Progression Humans Neoplasm Staging Progression-Free Survival Risk Assessment Risk Factors Time Factors Urinary Bladder Neoplasms/mortality/pathology/*therapy Urothelium/*pathology Bacillus Calmette-Guérin therapy Bladder cancer Bladder sparing Immediate cystectomy Micropapillary Prognosis Transurethral resection Urothelial carcinoma Variant histology

25-Hydroxyvitamin D3 1-alpha-Hydroxylase/metabolism Cell Line Tumor Humans Receptors Calcitriol/metabolism Risk Factors Signal Transduction Urinary Bladder Neoplasms/*blood/etiology/metabolism Vitamin D/*analogs & derivatives/blood/metabolism Vitamin D Deficiency/*blood/complications/metabolism 1 25(oh)(2)d 1α-hydroxylase Bladder cancer Cathelicidin Vitamin D

*DNA Methylation DNA Neoplasm/*metabolism Humans Prognosis Urinary Bladder Neoplasms/*diagnosis/*genetics Biomarker Bladder cancer DNA methylation Overall survival Progression-free survival

Carcinoma Transitional Cell/*diagnostic imaging/pathology/surgery Cystectomy Humans Lymph Nodes/*diagnostic imaging/pathology Lymphatic Metastasis/diagnostic imaging Magnetic Resonance Imaging Neoplasm Staging Positron Emission Tomography Computed Tomography Sensitivity and Specificity Tomography X-Ray Computed Urinary Bladder Neoplasms/*diagnostic imaging/pathology/surgery Bladder cancer Computed tomography Positron emission tomography Transitional cell carcinoma

*Cancer Survivors Humans *Quality of Life Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/*therapy

Cystectomy/*methods Humans Organ Sparing Treatments/*methods Treatment Outcome Urinary Bladder Neoplasms/*surgery Bladder preservation High-grade non-muscle-invasive bladder cancer Meta-analysis Radical cystectomy PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abdominal Muscles/*physiopathology Female *Health Services Needs and Demand Humans Middle Aged Neoplasm Metastasis/*physiopathology Quality of Life/*psychology *Social Support Urinary Bladder Neoplasms/*psychology/*secondary/therapy Bladder cancer Concerns Continent diversion Quality of life Systematic review Unmet supportive care needs