Cystectomy Humans Lasers Neoplasm Recurrence Local/surgery *Urinary Bladder Neoplasms/radiotherapy/surgery Urologic Surgical Procedures Bladder cancer Laser surgery Transurethral resection

Cystoscopy Fluorescence Recurrence rate Recurrence-free survival Urinary bladder neoplasms

Adult Carotenoids Female Humans Lutein Male *Urinary Bladder Neoplasms/epidemiology/prevention & control Zeaxanthins beta Carotene bladder cancer blood diet lycopene zeaxanthin α-carotene β-carotene β-cryptoxanthin

Combined Modality Therapy Humans Light Narrow Band Imaging *Urinary Bladder Neoplasms/diagnostic imaging/surgery cystoscopy recurrence urinary bladder neoplasms

Animals *Cheese Cohort Studies Dairy Products Diet Humans Milk Risk Factors *Urinary Bladder Neoplasms/epidemiology/etiology Yogurt

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Carcinoma Transitional Cell/*drug therapy/pathology Clinical Trials Phase II as Topic Clinical Trials Phase III as Topic Humans Neoplasm Metastasis Neoplasm Staging Practice Guidelines as Topic Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/*drug therapy/pathology Immune checkpoint inhibitors Platinum-based chemotherapy Survival outcomes Treatment guidelines Urothelial carcinoma funded this work. MK PK and SD are employees of Evidera.

Crohn's disease bladder cancer inflammatory bowel diseases meta-analysis ulcerative colitis commercial or financial relationships that could be construed as a potential conflict of interest.

Biomarkers Tumor/*metabolism Estrogen Receptor alpha/*metabolism Estrogen Receptor beta/*metabolism GATA3 Transcription Factor/*metabolism Humans Prognosis Urinary Bladder Neoplasms/diagnosis/*metabolism Gata3 bladder cancer estrogen receptors immunohistochemistry tumour markers commercial or financial relationships that could be construed as a potential conflict of interest.

Chemotherapy Adjuvant Humans Liquid Biopsy Muscles Neoplasm Invasiveness Prospective Studies *Urinary Bladder Neoplasms/drug therapy Cell-free DNA Circulating tumor cells Liquid biopsies Muscle-invasive bladder cancer Perioperative therapy

Administration Intravesical *Aneurysm Infected/therapy Aorta Humans *Mycobacterium bovis *Urinary Bladder Neoplasms/drug therapy

Administration Intravesical BCG Vaccine/*adverse effects/*therapeutic use Humans Meta-Analysis as Topic Randomized Controlled Trials as Topic *Systematic Reviews as Topic Urinary Bladder Neoplasms/*drug therapy

T1G3膀胱癌 根治性膀胱切除术 保留膀胱

Carcinoma Transitional Cell/*classification/*genetics/mortality Humans Predictive Value of Tests Survival Rate Treatment Outcome Urinary Bladder Neoplasms/*classification/*genetics/mortality Bladder cancer Molecular classification Molecular subtype Prognosis Progression Urothelial carcinoma

Carcinoma in Situ/*diagnosis/*therapy Humans Treatment Outcome Urinary Bladder Neoplasms/*diagnosis/*therapy Bladder cancer Carcinoma in situ Non–muscle-invasive bladder cancer

cohort study intravesical recurrence meta-analysis nomogram preoperative urine cytology upper urinary tract urothelial carcinoma commercial or financial relationships that could be construed as a potential conflict of interest.

Adjuvants Immunologic/*administration & dosage Administration Intravesical BCG Vaccine/*administration & dosage Humans *Lymphocytes Tumor-Infiltrating Treatment Outcome Urinary Bladder Neoplasms/*drug therapy/immunology/*pathology

Urinary bladder neoplasms adjuvant chemotherapy meta-analysis neoadjuvant chemotherapy (NAC) form (available at http://dx.doi.org/10.21037/tau-20-571). Dr. XZ serves as an unpaid editorial board member of Translational Andrology and Urology from Mar 2015 to Feb 2021. The other authors have no conflicts of interest to declare.

Adjuvants Immunologic/administration & dosage Administration Intravesical Antibiotics Antineoplastic/administration & dosage/adverse effects Antimetabolites Antineoplastic/*administration & dosage/adverse effects BCG Vaccine/administration & dosage Bias Cause of Death Confidence Intervals Deoxycytidine/administration & dosage/adverse effects/*analogs & derivatives Disease Progression Drug Administration Schedule Humans Mitomycin/administration & dosage/adverse effects Neoplasm Recurrence Local/*drug therapy/mortality/prevention & control Randomized Controlled Trials as Topic Saline Solution/administration & dosage Urinary Bladder Neoplasms/*drug therapy/mortality/pathology/prevention & control Gemcitabine

Aged *Brachytherapy Combined Modality Therapy Disease-Free Survival Female Humans Male Middle Aged Neoplasm Recurrence Local *Urinary Bladder Neoplasms/mortality/pathology/radiotherapy external beam radiotherapy interstitial brachytherapy muscle-invasive bladder cancer organ preservation

Aged Biomarkers/*blood C-Reactive Protein/analysis Cystectomy/*methods Female Humans Leukocyte Count Lymphocytes/pathology Male Middle Aged Neutrophils/pathology Platelet Count Preoperative Period Prognosis Proportional Hazards Models Retrospective Studies Urinary Bladder Neoplasms/blood/*mortality/*surgery Hematologic biomarker Meta-analysis Urothelial carcinoma of the bladder