*Biomarkers Tumor Carcinoma Transitional Cell/*genetics/mortality/pathology *DNA Methylation Humans Neoplasm Invasiveness Prognosis Risk Assessment Survival Rate Urinary Bladder Neoplasms/*genetics/mortality/pathology Biomarkers Dna High-risk non–muscle-invasive bladder cancer Methylation Prognostic markers Systematic review molecular markers

Arylamine N-Acetyltransferase/*genetics Asian People/genetics Humans *Polymorphism Single Nucleotide Smoking/epidemiology Urinary Bladder Neoplasms/epidemiology/ethnology/*genetics White People/genetics Bladder cancer Meta-analysis N-acetyltransferase 2 Polymorphism competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Biomarkers Tumor/*metabolism Humans RNA Long Noncoding/*metabolism Urinary Bladder Neoplasms/*diagnosis/*genetics/pathology bladder cancer lncRNAs meta-analysis non-invasive diagnosis

Biomarkers/urine DNA Mutational Analysis DNA Neoplasm/*urine Disease Progression Humans Mutation Neoplasm Recurrence Local/*diagnosis/genetics/*urine Sensitivity and Specificity Urinary Bladder Neoplasms/*diagnosis/genetics/*urine #BladderCancer #blcsm biomarkers molecular diagnostics urinary bladder neoplasms urine analysis Amsterdam UMC location VUmc. J. Bosschieter R.D.M. Steenbergen and J.A. Nieuwenhuijzen are inventors on patent(s) related to the work.

Anesthetics Local/*therapeutic use *Cystoscopy Humans Lidocaine/*therapeutic use Male Pain Management/*methods Pain Measurement Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/diagnosis/therapy administration cystoscopy intravesical lidocaine pain procedural urinary bladder neoplasms

Blood Loss Surgical/statistics & numerical data Blood Transfusion/statistics & numerical data Cystectomy/*adverse effects/methods Hospital Mortality Humans Length of Stay/statistics & numerical data Operative Time Postoperative Complications/*epidemiology/etiology Quality of Life Risk Factors Robotic Surgical Procedures/*adverse effects Treatment Outcome Urinary Bladder/surgery Urinary Bladder Neoplasms/*surgery Urinary Diversion/*adverse effects/methods health-related quality of life meta-analysis open radical cystectomy postoperative complication robot-assisted radical cystectomy

*DNA Methylation DNA Neoplasm/*metabolism Humans Prognosis Urinary Bladder Neoplasms/*diagnosis/*genetics Biomarker Bladder cancer DNA methylation Overall survival Progression-free survival

Humans Psychometrics *Quality of Life Surveys and Questionnaires Urinary Bladder Neoplasms/*therapy Calidad de vida Estudios de validación Neoplasias de la vejiga urinaria Neoplasms of the urinary bladder Quality of life Validation studies

Adult Aged Aged 80 and over Checklist Consensus Databases Factual Female Humans Male Middle Aged *Patient Reported Outcome Measures Psychometrics/methods/*standards Surveys and Questionnaires/*standards *Urinary Bladder Neoplasms Cosmin bladder cancer patient reported outcome measures psychometric properties systematic review

Asian People/genetics Carcinoma Renal Cell/genetics Female Genetic Association Studies/*methods Genetic Predisposition to Disease Humans Kidney Neoplasms/genetics Male *Polymorphism Single Nucleotide Prostatic Neoplasms/genetics Urinary Bladder Neoplasms/genetics Urogenital Neoplasms/*genetics Vascular Endothelial Growth Factor A/*genetics Meta-analysis Polymorphism Urologic neoplasms Vascular endothelial growth factors

*Genetic Association Studies *Genetic Predisposition to Disease Genotype Glutathione Transferase/*genetics Humans Odds Ratio *Polymorphism Genetic Publication Bias Risk Urinary Bladder Neoplasms/*genetics Bladder cancer Gstm1 Gstp1 Gstt1 Gene polymorphism Meta-analysis PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

*Cost-Benefit Analysis Cystectomy/*economics/*methods Humans *Laparoscopy *Robotic Surgical Procedures Urinary Bladder Neoplasms/*economics/*surgery

*DNA Methylation Disease Progression Female Genes APC/*physiology Humans Male *Promoter Regions Genetic *Urinary Bladder Neoplasms/genetics/pathology/urine

*Cystectomy/adverse effects/methods Humans Neoplasm Staging Neoplasm Residual/pathology/surgery *Reoperation/methods/statistics & numerical data *Urinary Bladder Neoplasms/pathology/surgery Cystoscopy Meta-analysis Neoplasm recurrence Urinary bladder neoplasms

Urinary bladder cancer characteristics prognosis review conflicts of interest with respect to the research authorship and/or publication of this article.

Cystectomy Humans Procedures and Techniques Utilization/*statistics & numerical data Prospective Studies Retrospective Studies Risk Assessment Urinary Bladder Neoplasms/*surgery Predictors Radical cystectomy Use Utilization interest including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg employment/affiliation grants or funding consultancies honoraria stock ownership or options expert testimony royalties or patents filed received or pending) are the following: None.

Antigenic Variation Antigens Neoplasm/*genetics Asian People GPI-Linked Proteins/genetics *Genetic Predisposition to Disease Humans Male Neoplasm Proteins/*genetics Polymorphism Single Nucleotide Urinary Bladder Neoplasms/*genetics White People

bladder cancer clinicopathological characteristics lncRNA prognosis

Carcinogens Environmental/adverse effects Gene-Environment Interaction Humans Incidence Occupational Exposure/adverse effects Prevalence Risk Assessment Risk Factors Smoking/adverse effects/epidemiology Time Factors Urinary Bladder Neoplasms/diagnosis/*epidemiology/genetics/mortality Bladder Cancer Epidemiology Urothelial

Arylamine N-Acetyltransferase/*genetics Genotype Humans Isoenzymes/*genetics Phenotype Polymorphism Genetic Urinary Bladder Neoplasms/*enzymology/*genetics N-Acetyltransferase Nat1 genetic polymorphism meta-analysis smoking systematic review urinary bladder cancer