Adjuvants Immunologic/*administration & dosage Administration Intravesical BCG Vaccine/*administration & dosage Humans *Lymphocytes Tumor-Infiltrating Treatment Outcome Urinary Bladder Neoplasms/*drug therapy/immunology/*pathology

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Chemotherapy Adjuvant/methods Cisplatin/therapeutic use Clinical Decision-Making/methods *Cystectomy Disease-Free Survival Female Humans Male Neoadjuvant Therapy/methods Neoplasm Recurrence Local/*epidemiology/pathology/prevention & control Neoplasm Staging Patient Selection *Sex Factors Urinary Bladder/pathology/surgery Urinary Bladder Neoplasms/mortality/pathology/*therapy Adjuvant chemotherapy Bladder cancer Gender Meta-analysis Neoadjuvant chemotherapy

Humans Quality of Life Retrospective Studies *Sarcopenia/epidemiology/etiology *Urinary Bladder Neoplasms/complications/epidemiology Bladder cancer Prevalence Sarcopenia Systematic review

5-alpha Reductase Inhibitors/therapeutic use Androgen Antagonists/therapeutic use Androgens/therapeutic use *Carcinoma in Situ Humans Male *Prostatic Neoplasms/pathology *Urinary Bladder Neoplasms/pathology *Androgen suppression therapy *Androgens *Bladder cancer *Incidence *Recurrence *Systematic review

Data Systems Humans *Multiparametric Magnetic Resonance Imaging Neoplasm Invasiveness Predictive Value of Tests Reproducibility of Results Urinary Bladder Neoplasms/*diagnostic imaging/pathology Bladder cancer Magnetic resonance imaging Meta-analysis Muscle invasive Systematic review Vesical Imaging Reporting and Data System

Biomarkers/urine DNA Mutational Analysis DNA Neoplasm/*urine Disease Progression Humans Mutation Neoplasm Recurrence Local/*diagnosis/genetics/*urine Sensitivity and Specificity Urinary Bladder Neoplasms/*diagnosis/genetics/*urine #BladderCancer #blcsm biomarkers molecular diagnostics urinary bladder neoplasms urine analysis Amsterdam UMC location VUmc. J. Bosschieter R.D.M. Steenbergen and J.A. Nieuwenhuijzen are inventors on patent(s) related to the work.

Aged Carcinoma Transitional Cell/*surgery *Cystectomy/methods Female Humans *Lymph Node Excision Male Middle Aged Postoperative Complications Randomized Controlled Trials as Topic Treatment Outcome Urinary Bladder Neoplasms/*surgery

Coloring Agents Humans Indocyanine Green Lymph Node Excision *Lymphatic Metastasis/diagnostic imaging *Lymphography Male Pelvis *Prostatic Neoplasms/diagnostic imaging/pathology Sentinel Lymph Node Biopsy *Urinary Bladder Neoplasms/diagnostic imaging/pathology Cáncer de Próstata Ganglio centinela Linfadenectomía Lymph node dissection Prostate cáncer Sentinel lymph node Verde de Indocianina

Anastomosis Surgical/adverse effects/instrumentation/methods Constriction Pathologic/etiology Cystectomy/*instrumentation/methods Humans Ileum/surgery Incidence Postoperative Complications/etiology Stents/*adverse effects Ureter/surgery Ureteral Obstruction/*etiology Urinary Bladder Neoplasms/surgery Urinary Catheters/adverse effects Urinary Diversion/adverse effects/*instrumentation/methods Cystectomy Internal double-J stent Orthotopic neobladder Ureteroileal anastomosis stricture Urinary diversion

肌层浸润性膀胱癌 保留膀胱 根治性切除 Meta分析 疗效评价

B7-H1 Antigen/*metabolism Biomarkers Tumor/metabolism Carcinoma Transitional Cell/metabolism/*mortality/pathology Cell Membrane/metabolism Gene Expression Regulation Neoplastic Humans Neoplasm Staging Prognosis Survival Analysis *Up-Regulation Urinary Bladder Neoplasms/metabolism/*mortality/pathology Biomarker Meta-analysis Pd-l1 Urothelial carcinoma

Cystectomy/methods/*mortality Humans Lymph Node Excision/methods/*mortality Lymph Nodes/surgery Lymphatic Metastasis Pelvis/pathology Postoperative Complications/etiology Prognosis Randomized Controlled Trials as Topic Survival Rate Treatment Outcome Urinary Bladder Neoplasms/*mortality/pathology/*surgery

Cystectomy/*methods Humans Organ Sparing Treatments/*methods Treatment Outcome Urinary Bladder Neoplasms/*surgery Bladder preservation High-grade non-muscle-invasive bladder cancer Meta-analysis Radical cystectomy PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

肌层浸润性膀胱癌 根治性膀胱切除术 保留膀胱 放化疗 Meta分析

长链非编码RNA 膀胱癌 预后 Meta分析

*DNA Methylation Disease Progression Female Genes APC/*physiology Humans Male *Promoter Regions Genetic *Urinary Bladder Neoplasms/genetics/pathology/urine

Administration Intravesical Antineoplastic Agents/*administration & dosage Humans Infusions Intra-Arterial Meta-Analysis as Topic Systematic Reviews as Topic Urinary Bladder Neoplasms/*drug therapy

Adult Case-Control Studies Child Environmental Exposure/*adverse effects/analysis Humans Odds Ratio Risk Factors Tobacco Smoke Pollution/*adverse effects/analysis Urinary Bladder Neoplasms/*epidemiology Workplace bladder cancer exposure to environmental tobacco smoke lifetime exposure meta-analysis

Cystectomy/*methods Humans Robotic Surgical Procedures/*methods Urinary Bladder Neoplasms/*surgery

Biomarkers Tumor/analysis Carcinoma Papillary/diagnosis/pathology Carcinoma Transitional Cell/diagnosis/pathology Humans Keratin-20/analysis/biosynthesis Prognosis Urinary Bladder Neoplasms/diagnosis/pathology Urologic Neoplasms/diagnosis/*pathology Urothelium/*pathology Cytokeratin 20 Molecular subtyping Thelial carcinoma Uro Urothelial lesions Variant histology