Humans *BCG Vaccine/adverse effects *Urinary Bladder Neoplasms/drug therapy BCG vaccine administration intravesical systematic review urinary bladder neoplasms

Humans Cystectomy/adverse effects/methods *Urinary Bladder Neoplasms/surgery/etiology Urinary Bladder *Urinary Diversion/adverse effects/methods *Acidosis/epidemiology/etiology/therapy Acidosis metabólica Bicarbonate Bicarbonato Bladder tumor Cistectomía radical Derivación urinaria Metabolic acidosis Radical cystectomy Tratamiento Treatment Tumor vesical Urinary diversion

Humans *Urinary Bladder Neoplasms/surgery/pathology Urologic Surgical Procedures Cystectomy *Laser Therapy *Lasers Solid-State/therapeutic use Turbt bladder tumor laser resection recurrence

Humans Photosensitizing Agents/therapeutic use Neoplasm Residual Neoplasm Recurrence Local/prevention & control *Photochemotherapy/methods Randomized Controlled Trials as Topic *Urinary Bladder Neoplasms/drug therapy/surgery/diagnosis Aminolevulinic Acid/therapeutic use Cystoscopy/methods Cystoscopy Fluorescent cystoscopy Hexaminolevulinate Meta-analysis Nonmuscle invasive bladder cancer Urinary bladder neoplasms conflicts of interest in the manuscript and during the submission process. This manuscript has not been published and is not under consideration for publication elsewhere.

Humans Mitomycin Gemcitabine Hematuria *Non-Muscle Invasive Bladder Neoplasms Deoxycytidine/therapeutic use Administration Intravesical *Urinary Bladder Neoplasms/drug therapy *Cystitis Chemical cystitis Cistitis química Cáncer de vejiga sin invasión muscular Gemcitabina intravesical Intravesical gemcitabine Intravesical mitomycin Mitomicina intravesical Non-muscle invasive bladder cancer Recurrence rates Tasas de recurrencia

Humans Mitomycin/therapeutic use Antibiotics Antineoplastic BCG Vaccine/therapeutic use *Non-Muscle Invasive Bladder Neoplasms Neoplasm Recurrence Local/drug therapy *Urinary Bladder Neoplasms/pathology Administration Intravesical Neoplasm Invasiveness Bladder cancer Device-assisted Emda Intravesical drug administration Nmibc

androgen suppression therapy bladder cancer incidence meta-analysis recurrence commercial or financial relationships that could be construed as a potential conflict of interest.

*Carcinoma Transitional Cell/drug therapy Humans Organoids Precision Medicine *Urinary Bladder Neoplasms/drug therapy Urothelium/pathology Metastases Personalized medicine Stem cells Transurethral resection

Humans *Carcinoma Transitional Cell *Urinary Bladder Neoplasms/pathology Retrospective Studies BCG Vaccine/therapeutic use Administration Intravesical Adjuvants Immunologic *Organ Transplantation Neoplasm Invasiveness Neoplasm Recurrence Local/pathology Bcg Bladder cancer Chemotherapy Mitomycin Transplanted patients

Bacillus Calmette-Guérin Chemoablation Epirubicin Gemcitabine Intravesical therapy Mitomycin Non–muscle-invasive bladder cancer

Blood Transfusion/*mortality Combined Modality Therapy Cystectomy/*mortality Humans *Perioperative Care Prognosis Survival Rate Urinary Bladder Neoplasms/pathology/*therapy Bladder cancer Blood transfusion Cystectomy Meta-analysis Oncology Systematic review

Bladder cancer Intra-arterial chemotherapy Intravesical chemotherapy Recurrence Survival

bladder cancer gemcitabine intravesical chemotherapy

Aged Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Carcinoma Transitional Cell/*drug therapy/*pathology Female Humans Immune Checkpoint Inhibitors/*therapeutic use Liver Neoplasms/secondary Male Middle Aged Survival Analysis Urinary Bladder Neoplasms/*drug therapy/*pathology bladder cancer immune checkpoint inhibitors immunotherapy meta-analysis urothelial carcinoma

Cystoscopy Humans Narrow Band Imaging/methods Neoplasm Recurrence Local Randomized Controlled Trials as Topic *Urinary Bladder Neoplasms/diagnostic imaging/drug therapy/surgery

Administration Intravesical Combined Modality Therapy Cystectomy/*methods Humans Neoplasm Recurrence Local/*epidemiology Network Meta-Analysis Randomized Controlled Trials as Topic Urethra Urinary Bladder Neoplasms/*diagnostic imaging/drug therapy/epidemiology/*surgery #BladderCancer #blcsm #uroonc blue-light cystoscopy hexaminolevulinic acid narrow band imaging non-muscle-invasive urothelial carcinoma photodynamic diagnosis single immediate intravesical chemotherapy

Humans Carboplatin/therapeutic use *Carcinoma Transitional Cell/drug therapy *Urinary Bladder Neoplasms Carboplatin Cisplatin Immune checkpoint inhibitors Platinum-based chemotherapy Urothelial carcinoma

bladder cancer checkpoint inhibitors chemotherapy immunotherapy radical cystectomy design of the study in the collection analyses or interpretation of data in the writing of the manuscript or in the decision to publish the results.

Cisplatin/adverse effects Humans *Immunotherapy/adverse effects/methods *Muscles/pathology *Neoadjuvant Therapy/adverse effects Neoplasm Staging *Urinary Bladder Neoplasms/drug therapy/pathology/therapy chemoimmunotherapy immunotherapy meta-analysis muscle-invasive bladder cancer (MIBC) neoadjuvant commercial or financial relationships that could be construed as a potential conflict of interest.

Humans *Neoplasm Recurrence Local/drug therapy *Urinary Bladder Neoplasms/pathology Infusions Intra-Arterial Chemotherapy Adjuvant Adverse Reactions bladder cancer intra-arterial chemotherapy meta-analysis prognosis