Biomarkers Tumor/analysis Carcinoma Papillary/diagnosis/pathology Carcinoma Transitional Cell/diagnosis/pathology Humans Keratin-20/analysis/biosynthesis Prognosis Urinary Bladder Neoplasms/diagnosis/pathology Urologic Neoplasms/diagnosis/*pathology Urothelium/*pathology Cytokeratin 20 Molecular subtyping Thelial carcinoma Uro Urothelial lesions Variant histology

Female Humans Male Prospective Studies Sex Factors Urinary Bladder Neoplasms/*etiology Urinary Tract Infections/*complications Bladder cancer Cystitis Urinary bladder neoplasms Urinary tract infections Urothelial carcinoma

Carcinogens Environmental/adverse effects Gene-Environment Interaction Humans Incidence Occupational Exposure/adverse effects Prevalence Risk Assessment Risk Factors Smoking/adverse effects/epidemiology Time Factors Urinary Bladder Neoplasms/diagnosis/*epidemiology/genetics/mortality Bladder Cancer Epidemiology Urothelial

bladder cancer circulating tumor cells (CTCs) meta-analysis prognosis urothelial cancer

Ki-67 bladder cancer meta-analysis prognosis urothelial carcinoma

Biomarkers Tumor/*urine Carcinoma Transitional Cell/pathology/*urine Gene Expression Regulation Neoplastic Humans Prognosis RNA Long Noncoding/*urine Urinary Bladder Neoplasms/pathology/*urine Bladder cancer biomarker diagnosis long non-coding RNA urothelial carcinoma–associated 1

Carcinoma Transitional Cell/pathology/*surgery Cystectomy/*methods Humans Kaplan-Meier Estimate Neoplasm Recurrence Local Risk Factors Urethra/*pathology Urinary Bladder/pathology/surgery Urinary Bladder Neoplasms/pathology/*surgery Bladder cancer Neobladder Radical cystectomy Urethral recurrence Urothelial carcinoma

Humans *Hyperthermia Induced Treatment Outcome Urinary Bladder Neoplasms/*therapy Bladder cancer chemohyperthermia radiohyperthermia regional hyperthermia therapy urothelial carcinoma

*Health Status Humans *Life Style *Quality of Life Survivors/*psychology Urinary Bladder Neoplasms/*psychology/therapy Bladder cancer Diet Exercise Lifestyle factors Quality of life Smoking Urothelial carcinoma

Kaplan-Meier Estimate Neoplasm Grading Neoplasm Metastasis Neoplasm Staging Odds Ratio Prognosis Publication Bias Urinary Bladder Neoplasms/*mortality/*pathology/therapy histological variants squamous differentiation urothelial carcinoma of the bladder including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg employment/affiliation grants or funding consultancies honoraria stock ownership or options expert testimony royalties or patents filed received or pending) are the following: None.

Biomarkers Tumor/genetics DNA Methylation Epigenesis Genetic *Gene Expression Regulation Neoplastic Humans Prognosis Retrospective Studies Urinary Bladder Neoplasms/*genetics Chromatin remodeling Methylation Non-coding RNA Progression Recurrence Urothelial carcinoma