Administration Intravesical Antineoplastic Agents/administration & dosage Combined Modality Therapy Cystectomy/methods Humans Randomized Controlled Trials as Topic Saline Solution/*administration & dosage/adverse effects Therapeutic Irrigation/adverse effects/methods Treatment Outcome Urethra Urinary Bladder Neoplasms/drug therapy/surgery/*therapy Continuous saline bladder irrigation Meta-analysis Non-muscle invasive bladder cancer Randomized controlled trials Transurethral resection of bladder tumors

Diabetes Mellitus Type 2/*drug therapy Dose-Response Relationship Drug Humans Hypoglycemic Agents/*adverse effects Incidence Observational Studies as Topic Pioglitazone/*adverse effects Risk Factors Urinary Bladder Neoplasms/*chemically induced

Humans Psychometrics *Quality of Life Surveys and Questionnaires Urinary Bladder Neoplasms/*therapy Calidad de vida Estudios de validación Neoplasias de la vejiga urinaria Neoplasms of the urinary bladder Quality of life Validation studies

Carcinoma in Situ/diagnosis/epidemiology/*pathology/surgery *Cystectomy Disease-Free Survival Humans Neoplasm Recurrence Local/*diagnosis/epidemiology/pathology Prognosis Survival Analysis Treatment Outcome Ureteral Neoplasms/*diagnosis/epidemiology/pathology/secondary Urinary Bladder/pathology/surgery Urinary Bladder Neoplasms/mortality/*pathology/surgery

Adult Aged Aged 80 and over Checklist Consensus Databases Factual Female Humans Male Middle Aged *Patient Reported Outcome Measures Psychometrics/methods/*standards Surveys and Questionnaires/*standards *Urinary Bladder Neoplasms Cosmin bladder cancer patient reported outcome measures psychometric properties systematic review

Asian People/genetics Carcinoma Renal Cell/genetics Female Genetic Association Studies/*methods Genetic Predisposition to Disease Humans Kidney Neoplasms/genetics Male *Polymorphism Single Nucleotide Prostatic Neoplasms/genetics Urinary Bladder Neoplasms/genetics Urogenital Neoplasms/*genetics Vascular Endothelial Growth Factor A/*genetics Meta-analysis Polymorphism Urologic neoplasms Vascular endothelial growth factors

*Genetic Association Studies *Genetic Predisposition to Disease Genotype Glutathione Transferase/*genetics Humans Odds Ratio *Polymorphism Genetic Publication Bias Risk Urinary Bladder Neoplasms/*genetics Bladder cancer Gstm1 Gstp1 Gstt1 Gene polymorphism Meta-analysis PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Carcinoma Transitional Cell/*pathology Humans *Sentinel Lymph Node Biopsy Urinary Bladder Neoplasms/*pathology Bladder Cancer Sentinel lymph mode

Female *Health Status Humans Male Middle Aged *Quality of Life Surveys and Questionnaires Treatment Outcome Urinary Bladder/*surgery Urinary Bladder Neoplasms/*surgery Urinary Diversion/*methods Urinary Reservoirs Continent Bladder cancer Meta-analysis Quality of life Urinary diversion

*Cost-Benefit Analysis Cystectomy/*economics/*methods Humans *Laparoscopy *Robotic Surgical Procedures Urinary Bladder Neoplasms/*economics/*surgery

*DNA Methylation Disease Progression Female Genes APC/*physiology Humans Male *Promoter Regions Genetic *Urinary Bladder Neoplasms/genetics/pathology/urine

Cystectomy/*methods Humans Length of Stay Postoperative Care/*methods Postoperative Complications/*epidemiology Prospective Studies Recovery of Function Retrospective Studies Standard of Care Urinary Bladder Neoplasms/rehabilitation/*surgery bladder cancer enhanced recovery after surgery meta-analysis postoperative rehabilitation radical cystectomy

Adolescent Adult Aged Aged 80 and over Animals Cultured Milk Products *Dairy Products *Diet Dietary Fats/administration & dosage *Feeding Behavior Female Humans Male Middle Aged Milk *Urinary Bladder Neoplasms/etiology/prevention & control Young Adult dairy products fermented dairy products whole milk bladder cancer meta-analysis systematic review

*Cystectomy/adverse effects/methods Humans Neoplasm Staging Neoplasm Residual/pathology/surgery *Reoperation/methods/statistics & numerical data *Urinary Bladder Neoplasms/pathology/surgery Cystoscopy Meta-analysis Neoplasm recurrence Urinary bladder neoplasms

Female Humans Male Prospective Studies *Quality of Life Urinary Bladder Neoplasms/drug therapy/*psychology/radiotherapy Bladder cancer Chemotherapy Muscle-invasive bladder cancer Quality of life Urothelial cancer PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Body mass index diet dietary supplements prognosis urinary bladder cancer

Urinary bladder cancer characteristics prognosis review conflicts of interest with respect to the research authorship and/or publication of this article.

Biopsy/methods Carcinoma in Situ/*pathology/*therapy Humans Muscle Smooth Neoplasm Invasiveness Urinary Bladder Neoplasms/*pathology/therapy Biopsias aleatorias de vejiga Carcinoma in situ Non-muscle invasive bladder cancer Random bladder biopsies Tumor vesical no-músculo invasivo

*Cystectomy *Health Status Humans Patient Education as Topic/*methods Preoperative Care/*methods Relaxation Therapy/*methods Urinary Bladder Neoplasms/*surgery Bladder cancer Cystectomy Supportive intervention Systematic review PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Circulating Tumor DNA/*analysis/blood/urine Humans Reproducibility of Results Sensitivity and Specificity Urinary Bladder Neoplasms/*diagnosis/pathology CfDNA biomarkers diagnosis meta-analysis