Bladder-sparing strategy Clinical complete response Localized muscle-invasive bladder cancer Neoadjuvant Systemic treatment

Humans Aged Cystectomy/methods *Urinary Bladder Neoplasms/surgery Urinary Bladder *Urinary Diversion/methods Hospital Mortality Bladder cancer Complications Epidemiology Mortality Radical cystectomy Urinary diversions

Male Humans *Stomach Neoplasms/genetics *Urinary Bladder Neoplasms/genetics Urinary Bladder Membrane Proteins RNA Messenger Antigens Neoplasm/genetics Neoplasm Proteins GPI-Linked Proteins/genetics Psca cancer risk polymorphism rs2294008 (C/T)

Humans *Transurethral Resection of Bladder Neoplasm Recurrence Local/pathology *Urinary Bladder Neoplasms/diagnosis/surgery/pathology Prognosis Urologic Surgical Procedures Cystectomy Bladder cancer Css Os Pfs Rfs Transurethral resection of bladder tumors financial ties to disclose.

Bcg Instillation Intravesical Low dose Non–muscle-invasive bladder cancer

Humans Photosensitizing Agents/therapeutic use Neoplasm Residual Neoplasm Recurrence Local/prevention & control *Photochemotherapy/methods Randomized Controlled Trials as Topic *Urinary Bladder Neoplasms/drug therapy/surgery/diagnosis Aminolevulinic Acid/therapeutic use Cystoscopy/methods Cystoscopy Fluorescent cystoscopy Hexaminolevulinate Meta-analysis Nonmuscle invasive bladder cancer Urinary bladder neoplasms conflicts of interest in the manuscript and during the submission process. This manuscript has not been published and is not under consideration for publication elsewhere.

Humans Mitomycin Gemcitabine Hematuria *Non-Muscle Invasive Bladder Neoplasms Deoxycytidine/therapeutic use Administration Intravesical *Urinary Bladder Neoplasms/drug therapy *Cystitis Chemical cystitis Cistitis química Cáncer de vejiga sin invasión muscular Gemcitabina intravesical Intravesical gemcitabine Intravesical mitomycin Mitomicina intravesical Non-muscle invasive bladder cancer Recurrence rates Tasas de recurrencia

Male Humans *Papillomavirus Infections/complications/epidemiology/prevention & control Human Papillomavirus Viruses Mendelian Randomization Analysis Papillomaviridae/genetics Human papillomavirus 18 *Urinary Bladder Neoplasms/epidemiology/complications HPV prevalence bladder cancer human papillomavirus mendelian randomization meta-analysis

Humans Mitomycin/therapeutic use Antibiotics Antineoplastic BCG Vaccine/therapeutic use *Non-Muscle Invasive Bladder Neoplasms Neoplasm Recurrence Local/drug therapy *Urinary Bladder Neoplasms/pathology Administration Intravesical Neoplasm Invasiveness Bladder cancer Device-assisted Emda Intravesical drug administration Nmibc

Humans Female *Carcinoma Transitional Cell/chemically induced/epidemiology/genetics DNA Adducts/adverse effects *Drugs Chinese Herbal/adverse effects Taiwan/epidemiology *Urinary Bladder Neoplasms Carcinogens *Kidney Neoplasms/chemically induced/epidemiology/genetics *Aristolochic Acids/adverse effects/analysis *Ureteral Neoplasms/chemically induced/epidemiology *Urinary Tract Aristolochia DNA adduct Mass spectrometry Nephropathy Renal pelvic cancer Ureteral cancer

detrusor muscle en bloc resection of bladder tumor non-muscle invasive bladder cancer

bladder cancer germline monogenic gene pathogenic mutations risk

Humans Cost-Benefit Analysis *Early Detection of Cancer *Urinary Bladder Neoplasms/diagnosis/epidemiology

Humans *Obturator Nerve/physiology/surgery Network Meta-Analysis Transurethral Resection of Bladder *Urinary Bladder Neoplasms/surgery/pathology Reflex bladder cancer lumbar anesthesia obturator nerve block transurethral resection of bladder tumor conflicts of interest to declare.

Bladder cancer Hpv Human papillomavirus Meta-analysis

androgen suppression therapy bladder cancer incidence meta-analysis recurrence commercial or financial relationships that could be construed as a potential conflict of interest.

Humans *Carcinoma Transitional Cell *Urinary Bladder Neoplasms/pathology Retrospective Studies BCG Vaccine/therapeutic use Administration Intravesical Adjuvants Immunologic *Organ Transplantation Neoplasm Invasiveness Neoplasm Recurrence Local/pathology Bcg Bladder cancer Chemotherapy Mitomycin Transplanted patients

Cohort Studies *Dietary Fats/adverse effects Female Humans Male Prospective Studies Risk Factors Sugars *Urinary Bladder Neoplasms/epidemiology/etiology bladder cancer diet epidemiology fat oil risk factor

Cohort Studies Female Humans Male Prospective Studies Risk Factors Tea *Urinary Bladder Neoplasms/epidemiology/etiology Dose–response analysis Epidemiology Smoking Urinary bladder cancer

Bacillus Calmette-Guérin Chemoablation Epirubicin Gemcitabine Intravesical therapy Mitomycin Non–muscle-invasive bladder cancer