Cystectomy/*methods Humans Perioperative Care/*methods Postoperative Complications/epidemiology/prevention & control *Recovery of Function Standard of Care Urinary Bladder Neoplasms/*surgery Urologic Surgical Procedures/*methods

Blood Loss Surgical/statistics & numerical data Blood Transfusion/statistics & numerical data Cystectomy/*adverse effects/methods Hospital Mortality Humans Length of Stay/statistics & numerical data Operative Time Postoperative Complications/*epidemiology/etiology Quality of Life Risk Factors Robotic Surgical Procedures/*adverse effects Treatment Outcome Urinary Bladder/surgery Urinary Bladder Neoplasms/*surgery Urinary Diversion/*adverse effects/methods health-related quality of life meta-analysis open radical cystectomy postoperative complication robot-assisted radical cystectomy

Cystectomy/*methods Humans Length of Stay Nutritional Status *Perioperative Care Postoperative Complications/*epidemiology Urinary Bladder Neoplasms/*surgery Wound Healing

Carcinoma in Situ/diagnosis/epidemiology/*pathology/surgery *Cystectomy Disease-Free Survival Humans Neoplasm Recurrence Local/*diagnosis/epidemiology/pathology Prognosis Survival Analysis Treatment Outcome Ureteral Neoplasms/*diagnosis/epidemiology/pathology/secondary Urinary Bladder/pathology/surgery Urinary Bladder Neoplasms/mortality/*pathology/surgery

Cystectomy/*methods Humans Length of Stay Postoperative Care/*methods Postoperative Complications/*epidemiology Prospective Studies Recovery of Function Retrospective Studies Standard of Care Urinary Bladder Neoplasms/rehabilitation/*surgery bladder cancer enhanced recovery after surgery meta-analysis postoperative rehabilitation radical cystectomy

Adjuvants Immunologic/*therapeutic use Administration Intravesical BCG Vaccine/*therapeutic use Carcinoma Transitional Cell/pathology/*therapy Cystoscopy Female Humans Male Multivariate Analysis Muscle Smooth/*pathology Neoplasm Invasiveness Neoplasm Recurrence Local/*epidemiology Proportional Hazards Models Sex Factors Survival Rate Urinary Bladder Neoplasms/pathology/*therapy *Urologic Surgical Procedures Bladder cancer Gender differences Local recurrence Meta-analysis Transurethral resection of bladder tumor

Aged Biomarkers Tumor/*blood Cystectomy/*adverse effects Female Humans Leukocyte Count Lymphocytes/*pathology Male Middle Aged Monocytes/*pathology Neoplasm Recurrence Local/blood/*epidemiology Postoperative Complications/blood/*epidemiology Survival Analysis Urinary Bladder Neoplasms/*blood/pathology/surgery

Adult Case-Control Studies Child Environmental Exposure/*adverse effects/analysis Humans Odds Ratio Risk Factors Tobacco Smoke Pollution/*adverse effects/analysis Urinary Bladder Neoplasms/*epidemiology Workplace bladder cancer exposure to environmental tobacco smoke lifetime exposure meta-analysis

Alcohol Drinking/*adverse effects Female Humans Male Risk Assessment Urinary Bladder Neoplasms/*epidemiology/*etiology Alcohol consumption Bladder cancer Cancer risk

Carcinoma Transitional Cell/epidemiology/*surgery *Cystectomy Humans Kidney Neoplasms/*epidemiology Neoplasms Second Primary/*epidemiology Ureteral Neoplasms/*epidemiology Urethral Neoplasms/*epidemiology Urinary Bladder Neoplasms/*surgery Bladder cancer Radical cystectomy Recurrence Remnant Upper urinary tract Urethra Urothelium including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg employment/affiliation grants or funding consultancies honoraria stock ownership or options expert testimony royalties or patents filed received or pending) are the following: None.

Adenocarcinoma/epidemiology/*pathology/surgery Cystectomy/*methods Digital Rectal Examination Humans Incidental Findings Male Neoplasm Recurrence Local/pathology Prognosis Prostate/pathology Prostate-Specific Antigen Prostatectomy/*methods Prostatic Neoplasms/epidemiology/*pathology/surgery Survival Rate Urinary Bladder Neoplasms/*surgery bladder neoplasms cystectomy prostatectomy prostatic neoplasms

Carcinogens Environmental/adverse effects Gene-Environment Interaction Humans Incidence Occupational Exposure/adverse effects Prevalence Risk Assessment Risk Factors Smoking/adverse effects/epidemiology Time Factors Urinary Bladder Neoplasms/diagnosis/*epidemiology/genetics/mortality Bladder Cancer Epidemiology Urothelial

*Body Mass Index Cohort Studies Humans Odds Ratio Prospective Studies Risk Factors Urinary Bladder Neoplasms/*epidemiology/*etiology bladder cancer body mass index dose-response meta-analysis risk

Alleles Case-Control Studies *Genetic Predisposition to Disease Genotype Glutathione Transferase/*genetics Humans Odds Ratio *Polymorphism Genetic Publication Bias Risk Urinary Bladder Neoplasms/epidemiology/*genetics Gstm1 Gstt1 bladder cancer polymorphism

Aged *Coffee Cohort Studies Female Follow-Up Studies Humans Incidence Japan/epidemiology Male Middle Aged Prospective Studies Risk Factors Surveys and Questionnaires Urinary Bladder Neoplasms/diagnosis/*epidemiology/*prevention & control

Cardiovascular Diseases/*etiology Cohort Studies Humans Hypoglycemic Agents/*adverse effects/pharmacology Non-alcoholic Fatty Liver Disease/*etiology/pathology Pioglitazone Prevalence Risk Thiazolidinediones/*adverse effects/pharmacology Urinary Bladder Neoplasms/epidemiology/*etiology/pathology Bladder cancer Cardiovascular disease Non-alcoholic steatohepatitis

Diabetes Mellitus/diagnosis/*drug therapy/epidemiology Dose-Response Relationship Drug Humans Hypoglycemic Agents/*adverse effects Linear Models Multivariate Analysis Odds Ratio Pioglitazone Risk Assessment Risk Factors Thiazolidinediones/*adverse effects Time Factors Urinary Bladder Neoplasms/*chemically induced/diagnosis/epidemiology

Animals Cattle Diet/*adverse effects *Evidence-Based Medicine Food Preserved/*adverse effects Humans Incidence Meat/*adverse effects Meat Products/*adverse effects Reproducibility of Results Risk Factors Sheep Domestic Sus scrofa Urinary Bladder Neoplasms/epidemiology/*etiology Bladder cancer Dose–response Meta-analysis Processed meat Red meat

Acetylation Arylamine N-Acetyltransferase/*genetics/metabolism Asian People/genetics Case-Control Studies China/epidemiology Genetic Association Studies Genetic Predisposition to Disease Humans Odds Ratio Phenotype *Polymorphism Single Nucleotide Risk Assessment Risk Factors Urinary Bladder Neoplasms/enzymology/ethnology/*genetics

Biomarkers Tumor Case-Control Studies *DNA Methylation Death-Associated Protein Kinases/*genetics *Genetic Association Studies *Genetic Predisposition to Disease Humans Neoplasm Grading Neoplasm Staging Odds Ratio *Promoter Regions Genetic Publication Bias Risk Urinary Bladder Neoplasms/*epidemiology/*genetics/pathology