Biomarkers Tumor/*urine DNA Neoplasm/*urine Humans RNA Neoplasm/*urine Urinary Bladder Neoplasms/*genetics/*urine Watchful Waiting Biomarkers Bladder Genetic Surveillance

Cystectomy/*methods Humans Neoplasm Invasiveness Urethra Urinary Bladder Neoplasms/pathology/*surgery Bladder tumor En bloc resection Meta-analysis Transurethral resection

Biomarkers Tumor/genetics Carcinoma/genetics Gene Expression/genetics Gene Expression Profiling/methods Gene Expression Regulation Neoplastic/genetics Humans Neoplasm Recurrence Local/genetics Odds Ratio Prognosis RNA Circular/*genetics Survival Analysis Transcriptome/genetics Urinary Bladder/pathology Urinary Bladder Neoplasms/*genetics/metabolism bladder cancer circular RNA meta-analysis

*Biomarkers Tumor Carcinoma Transitional Cell/*genetics/mortality/pathology *DNA Methylation Humans Neoplasm Invasiveness Prognosis Risk Assessment Survival Rate Urinary Bladder Neoplasms/*genetics/mortality/pathology Biomarkers Dna High-risk non–muscle-invasive bladder cancer Methylation Prognostic markers Systematic review molecular markers

Biomarkers Tumor/*metabolism Humans RNA Long Noncoding/*metabolism Urinary Bladder Neoplasms/*diagnosis/*genetics/pathology bladder cancer lncRNAs meta-analysis non-invasive diagnosis

25-Hydroxyvitamin D3 1-alpha-Hydroxylase/metabolism Cell Line Tumor Humans Receptors Calcitriol/metabolism Risk Factors Signal Transduction Urinary Bladder Neoplasms/*blood/etiology/metabolism Vitamin D/*analogs & derivatives/blood/metabolism Vitamin D Deficiency/*blood/complications/metabolism 1 25(oh)(2)d 1α-hydroxylase Bladder cancer Cathelicidin Vitamin D

B7-H1 Antigen/*metabolism Biomarkers Tumor/metabolism Carcinoma Transitional Cell/metabolism/*mortality/pathology Cell Membrane/metabolism Gene Expression Regulation Neoplastic Humans Neoplasm Staging Prognosis Survival Analysis *Up-Regulation Urinary Bladder Neoplasms/metabolism/*mortality/pathology Biomarker Meta-analysis Pd-l1 Urothelial carcinoma

Biological Assay/methods Biomarkers Tumor/*urine Cystoscopy Humans Sensitivity and Specificity Urinary Bladder Neoplasms/diagnosis/*urine

Administration Intravesical Antineoplastic Agents/administration & dosage Combined Modality Therapy Cystectomy/methods Humans Randomized Controlled Trials as Topic Saline Solution/*administration & dosage/adverse effects Therapeutic Irrigation/adverse effects/methods Treatment Outcome Urethra Urinary Bladder Neoplasms/drug therapy/surgery/*therapy Continuous saline bladder irrigation Meta-analysis Non-muscle invasive bladder cancer Randomized controlled trials Transurethral resection of bladder tumors

Biopsy/methods Carcinoma in Situ/*pathology/*therapy Humans Muscle Smooth Neoplasm Invasiveness Urinary Bladder Neoplasms/*pathology/therapy Biopsias aleatorias de vejiga Carcinoma in situ Non-muscle invasive bladder cancer Random bladder biopsies Tumor vesical no-músculo invasivo

bladder tumor childhood exposure environmental smoking nonsmoking adult

Circulating Tumor DNA/*analysis/blood/urine Humans Reproducibility of Results Sensitivity and Specificity Urinary Bladder Neoplasms/*diagnosis/pathology CfDNA biomarkers diagnosis meta-analysis

Adjuvants Immunologic/*therapeutic use Administration Intravesical BCG Vaccine/*therapeutic use Carcinoma Transitional Cell/pathology/*therapy Cystoscopy Female Humans Male Multivariate Analysis Muscle Smooth/*pathology Neoplasm Invasiveness Neoplasm Recurrence Local/*epidemiology Proportional Hazards Models Sex Factors Survival Rate Urinary Bladder Neoplasms/pathology/*therapy *Urologic Surgical Procedures Bladder cancer Gender differences Local recurrence Meta-analysis Transurethral resection of bladder tumor

bladder cancer meta-analysis system review tumor associated macrophages

Aged Biomarkers Tumor/*blood Cystectomy/*adverse effects Female Humans Leukocyte Count Lymphocytes/*pathology Male Middle Aged Monocytes/*pathology Neoplasm Recurrence Local/blood/*epidemiology Postoperative Complications/blood/*epidemiology Survival Analysis Urinary Bladder Neoplasms/*blood/pathology/surgery

Biomarkers Tumor/*urine Humans Prognosis Urinary Bladder Neoplasms/*diagnosis/*urine Biomarker Bladder cancer Diagnosis Systematic review Urine

Biomarkers Tumor/analysis Carcinoma Papillary/diagnosis/pathology Carcinoma Transitional Cell/diagnosis/pathology Humans Keratin-20/analysis/biosynthesis Prognosis Urinary Bladder Neoplasms/diagnosis/pathology Urologic Neoplasms/diagnosis/*pathology Urothelium/*pathology Cytokeratin 20 Molecular subtyping Thelial carcinoma Uro Urothelial lesions Variant histology

bladder cancer circulating tumor cells (CTCs) meta-analysis prognosis urothelial cancer

Biomarkers Tumor/*urine Cystoscopy/methods *DNA Methylation Humans Urinary Bladder Neoplasms/*diagnosis/urine biomarkers methylation molecular diagnostics neoplasms urinary bladder urine analysis

Biomarkers Tumor/*urine Fibronectins/*urine Humans Prognosis Urinary Bladder Neoplasms/*diagnosis/urine Biomarker Bladder cancer Diagnosis Meta-analysis Urine fibronectin standards of institutional and international research committee this article is based on previous published studies thus it does not contain any studies with human participants or animals. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.