Adjuvant Chemotherapy Bladder-sparing Chemoradiation Enhanced Recovery after Surgery Muscle-invasive Bladder Cancer Neoadjuvant Chemotherapy Radical Cystectomy Transurethral Resection of Bladder Tumor Trimodal Urothelial Carcinoma of Bladder Variant Histology

Humans Aged Cystectomy/methods *Urinary Bladder Neoplasms/surgery Urinary Bladder *Urinary Diversion/methods Hospital Mortality Bladder cancer Complications Epidemiology Mortality Radical cystectomy Urinary diversions

Humans *Urinary Diversion/adverse effects *Ureter/surgery Cystectomy/methods Anastomosis Surgical/adverse effects *Vesico-Ureteral Reflux/etiology *Urinary Bladder Neoplasms/surgery Ileum/surgery *Pyelonephritis/complications Bladder Orthotopic ileal neobladder Radical cystectomy Tumor Ureteroenteric anastomosis Urinary diversion

Humans Cystectomy/adverse effects/methods *Urinary Bladder Neoplasms/surgery/etiology Urinary Bladder *Urinary Diversion/adverse effects/methods *Acidosis/epidemiology/etiology/therapy Acidosis metabólica Bicarbonate Bicarbonato Bladder tumor Cistectomía radical Derivación urinaria Metabolic acidosis Radical cystectomy Tratamiento Treatment Tumor vesical Urinary diversion

Humans *Urinary Bladder/pathology Cystectomy/methods Prognosis Prospective Studies Neoplasm Recurrence Local/pathology *Urinary Bladder Neoplasms/pathology Biomarkers biomarker neutrophil-to-lymphocyte ratio prognostic factor radical cystectomy recurrence urothelial carcinoma

bladder cancer checkpoint inhibitors chemotherapy immunotherapy radical cystectomy design of the study in the collection analyses or interpretation of data in the writing of the manuscript or in the decision to publish the results.

Bladder cancer neoadjuvant chemotherapy radical cystectomy systematic review variant histology urothelial cancer

*Cystectomy/adverse effects Humans Postoperative Complications/epidemiology/etiology Prospective Studies Retrospective Studies *Robotic Surgical Procedures/adverse effects *Robotics Treatment Outcome *Urinary Bladder Neoplasms/surgery Bladder cancer Intracorporeal Meta-analysis Radical cystectomy Robot-assisted

*Cystectomy Humans Prospective Studies Systematic Reviews as Topic Treatment Outcome Urinary Bladder/pathology/surgery *Urinary Bladder Neoplasms/pathology/surgery models mortality nomograms radical cystectomy urinary bladder neoplasms

Apoptosis B7-H1 Antigen/genetics/metabolism *Carcinoma Transitional Cell/pathology Cystectomy Humans Immune Checkpoint Inhibitors Ligands Lymph Node Excision Neoplasm Recurrence Local/pathology Prognosis Programmed Cell Death 1 Receptor Urinary Bladder *Urinary Bladder Neoplasms/pathology bladder urothelial carcinoma meta-analysis prognostic value programmed cell death ligand-1 radical cystectomy commercial or financial relationships that could be construed as a potential conflict of interest.

Radical cystectomy bladder preservation distant metastasis rate (DMR) muscular invasive bladder cancer (MIBC) survival rate form (available at https://dx.doi.org/10.21037/tau-21-564). The authors have no conflicts of interest to declare.

*Carcinoma Transitional Cell Cystectomy/adverse effects Humans Morbidity Smoking/adverse effects *Urinary Bladder Neoplasms/epidemiology/surgery Complication Infection Outcome Perioperative mortality Radical cystectomy Smoking exposure Urothelial bladder cancer

Cystectomy/*methods Humans Survival Analysis Urinary Bladder Neoplasms/mortality/*surgery Bladder cancer Delay Radical cystectomy Survival

Cystectomy/adverse effects Humans Postoperative Complications/diagnosis/epidemiology/etiology Risk Factors *Robotic Surgical Procedures/adverse effects *Robotics Treatment Outcome *Urinary Bladder Neoplasms/surgery Urologic Surgical Procedures *Urology Complications European Association of Urology guidelines Outcome reporting Robot-assisted radical cystectomy Standardised tool

Administration Intravesical BCG Vaccine/therapeutic use *Carcinoma in Situ/diagnosis/therapy Female Humans Male Neoplasm Invasiveness *Urinary Bladder Neoplasms/diagnosis/pathology/therapy *Urology *BCG unresponsive *Bacillus Calmette-Guerin (BCG) *Bladder cancer *Cystoscopy *Diagnosis *European Association of Urology (EAU) *Follow-up *Guidelines *Intravesical chemotherapy *Prognosis *Radical cystectomy *Transurethral resection (TUR) *Urothelial carcinoma

Radical cystectomy Vi-rads muscle-invasive bladder cancer urothelial carcinoma

Blood Loss Surgical/statistics & numerical data Cystectomy/*methods Humans Length of Stay/statistics & numerical data Lymph Node Excision *Minimally Invasive Surgical Procedures Operative Time Postoperative Complications/epidemiology Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/*surgery Bladder cancer Meta-analysis Minimally invasive Open radical cystectomy Randomized controlled trials

Cystectomy/*methods/rehabilitation Humans Robotic Surgical Procedures/*methods Urinary Bladder Neoplasms/*surgery Bladder cancer Laparoscopic Radical cystectomy Robotic assisted

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Chemotherapy Adjuvant *Cystectomy/methods Humans Neoadjuvant Therapy Neoplasm Invasiveness Survival Rate Urinary Bladder Neoplasms/*drug therapy/mortality/pathology/*surgery Muscle-invasive bladder cancer Neoadjuvant chemotherapy Overall survival Radical cystectomy

*Cystectomy/methods Humans Postoperative Complications/*epidemiology Prognosis Survival Rate Urinary Bladder Neoplasms/*mortality/*surgery Bladder cancer clinical markers morbidity mortality radical cystectomy survival