Aged *Brachytherapy Combined Modality Therapy Disease-Free Survival Female Humans Male Middle Aged Neoplasm Recurrence Local *Urinary Bladder Neoplasms/mortality/pathology/radiotherapy external beam radiotherapy interstitial brachytherapy muscle-invasive bladder cancer organ preservation

Antineoplastic Agents Immunological/*therapeutic use Carcinoma Transitional Cell/*drug therapy Humans Immunotherapy/*adverse effects/methods Network Meta-Analysis Salvage Therapy/*methods Urinary Bladder Neoplasms/*drug therapy Rct Uc Ucb adverse events chemotherapy immunotherapy network meta-analyses second-line

*Antibiotic Prophylaxis Bacteriuria/*prevention & control Humans Postoperative Complications/*prevention & control Urinary Bladder Neoplasms/*surgery Urinary Tract Infections/*prevention & control antibiotic prophylaxis bacteriuria carcinoma transitional cell health planning guidelines systematic review

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Chemotherapy Adjuvant/methods Cisplatin/therapeutic use Clinical Decision-Making/methods *Cystectomy Disease-Free Survival Female Humans Male Neoadjuvant Therapy/methods Neoplasm Recurrence Local/*epidemiology/pathology/prevention & control Neoplasm Staging Patient Selection *Sex Factors Urinary Bladder/pathology/surgery Urinary Bladder Neoplasms/mortality/pathology/*therapy Adjuvant chemotherapy Bladder cancer Gender Meta-analysis Neoadjuvant chemotherapy

Administration Intravesical Antibiotics Antineoplastic/*administration & dosage Antimetabolites Antineoplastic/*administration & dosage Deoxycytidine/administration & dosage/*analogs & derivatives Humans Mitomycin/*administration & dosage Neoplasm Invasiveness Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/*drug therapy/pathology Gemcitabine Bladder cancer Meta-analysis Mitomycin Systematic evaluation

Humans Neoplasm Recurrence Local/epidemiology/prevention & control Peer Review Prospective Studies Urinary Bladder *Urinary Bladder Neoplasms/surgery bladder cancer intravesical chemotherapy irrigation randomized controlled trial recurrence

Biomarkers Tumor Cystoscopy Humans Neoplasm Recurrence Local/diagnosis Network Meta-Analysis *Urinary Bladder Neoplasms/diagnosis Accuracy Bladder cancer Urinary biomarkers Urine cytology

Aged Biomarkers/*blood C-Reactive Protein/analysis Cystectomy/*methods Female Humans Leukocyte Count Lymphocytes/pathology Male Middle Aged Neutrophils/pathology Platelet Count Preoperative Period Prognosis Proportional Hazards Models Retrospective Studies Urinary Bladder Neoplasms/blood/*mortality/*surgery Hematologic biomarker Meta-analysis Urothelial carcinoma of the bladder

Administration Intravesical Antibiotics Antineoplastic/administration & dosage/*therapeutic use BCG Vaccine Carcinoma Transitional Cell/*drug therapy Humans Mitomycin/administration & dosage/*therapeutic use Randomized Controlled Trials as Topic Treatment Outcome Urinary Bladder Neoplasms/*drug therapy

Humans Quality of Life Retrospective Studies *Sarcopenia/epidemiology/etiology *Urinary Bladder Neoplasms/complications/epidemiology Bladder cancer Prevalence Sarcopenia Systematic review

Asia Asian People Humans *MicroRNAs/genetics *Urinary Bladder Neoplasms/diagnosis/genetics

Age of Onset Cohort Studies Female Hormones/*metabolism Humans Menopause Middle Aged Parity Prospective Studies *Reproduction Risk Assessment Risk Factors United States/epidemiology Urinary Bladder Neoplasms/epidemiology/*physiopathology Plco bladder cancer hormones meta-analysis reproductive factors interest.

Adult Caffeine/*adverse effects Central Nervous System Stimulants/adverse effects Coffee/*adverse effects Cytochrome P-450 CYP1A2 Dose-Response Relationship Drug Female Humans Male Middle Aged Risk Factors Smoking/*adverse effects Urinary Bladder Neoplasms/*etiology Bladder cancer Coffee consumption Cohort study Dose–response analyses Smoking

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Carcinoma Transitional Cell/immunology/mortality/pathology/*therapy Chemotherapy Adjuvant/methods/statistics & numerical data Clinical Trials Phase I as Topic Clinical Trials Phase II as Topic Cystectomy Disease-Free Survival Follow-Up Studies Humans Immune Checkpoint Inhibitors/*therapeutic use Muscle Smooth/pathology/surgery Neoadjuvant Therapy/*methods/statistics & numerical data Neoplasm Invasiveness/pathology Prospective Studies Treatment Outcome Urinary Bladder/pathology/surgery Urinary Bladder Neoplasms/immunology/mortality/pathology/*therapy Bladder cancer Immune checkpoint inhibitors Immunotherapy Neoadjuvant

*Anti-Infective Agents Humans *Urinary Bladder Neoplasms *Urinary Tract Infections Urologic Surgical Procedures

Cystectomy/adverse effects Humans Postoperative Complications/diagnosis/epidemiology/etiology Risk Factors *Robotic Surgical Procedures/adverse effects *Robotics Treatment Outcome *Urinary Bladder Neoplasms/surgery Urologic Surgical Procedures *Urology Complications European Association of Urology guidelines Outcome reporting Robot-assisted radical cystectomy Standardised tool

Carcinoma/*diagnosis/*therapy Humans Urinary Bladder Neoplasms/*diagnosis/*therapy Bladder cancer Clear cell carcinoma Systematic review Urinary bladder

Chemotherapy Adjuvant *Combined Modality Therapy Cystectomy Female Humans Middle Aged Muscles Neoadjuvant Therapy *Neoplasm Invasiveness Organ Sparing Treatments Patient Selection Quality of Life Salvage Therapy Survival Rate *Urinary Bladder Neoplasms/therapy

*Cystectomy/methods Humans *Nutritional Status Postoperative Complications/*epidemiology/mortality Preoperative Period Urinary Bladder Neoplasms/*surgery Bladder cancer Complications Cystectomy Mortality Nutritional status Sarcopenia

Aged Catheterization Female Hospitalization Humans Lasers Solid-State/*therapeutic use Male Middle Aged Muscles/*pathology Neoplasm Recurrence Local/pathology Postoperative Complications/etiology Publication Bias Treatment Outcome Urethral Stricture/surgery Urinary Bladder Neoplasms/pathology/*surgery *Urologic Surgical Procedures Holmium laser Meta-analysis Non-muscle-invasive bladder cancer Transurethral resection