Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Carcinoma Transitional Cell/immunology/mortality/pathology/*therapy Chemotherapy Adjuvant/methods/statistics & numerical data Clinical Trials Phase I as Topic Clinical Trials Phase II as Topic Cystectomy Disease-Free Survival Follow-Up Studies Humans Immune Checkpoint Inhibitors/*therapeutic use Muscle Smooth/pathology/surgery Neoadjuvant Therapy/*methods/statistics & numerical data Neoplasm Invasiveness/pathology Prospective Studies Treatment Outcome Urinary Bladder/pathology/surgery Urinary Bladder Neoplasms/immunology/mortality/pathology/*therapy Bladder cancer Immune checkpoint inhibitors Immunotherapy Neoadjuvant

Cystectomy/adverse effects Humans Postoperative Complications/diagnosis/epidemiology/etiology Risk Factors *Robotic Surgical Procedures/adverse effects *Robotics Treatment Outcome *Urinary Bladder Neoplasms/surgery Urologic Surgical Procedures *Urology Complications European Association of Urology guidelines Outcome reporting Robot-assisted radical cystectomy Standardised tool

Aged Catheterization Female Hospitalization Humans Lasers Solid-State/*therapeutic use Male Middle Aged Muscles/*pathology Neoplasm Recurrence Local/pathology Postoperative Complications/etiology Publication Bias Treatment Outcome Urethral Stricture/surgery Urinary Bladder Neoplasms/pathology/*surgery *Urologic Surgical Procedures Holmium laser Meta-analysis Non-muscle-invasive bladder cancer Transurethral resection

Adult Aged Aged 80 and over B7-H1 Antigen/genetics/*immunology Female Humans Immune Checkpoint Inhibitors/*administration & dosage *Immunotherapy Male Middle Aged Programmed Cell Death 1 Receptor/genetics/*immunology Progression-Free Survival Randomized Controlled Trials as Topic Treatment Outcome Urinary Bladder Neoplasms/genetics/immunology/mortality/*therapy efficacy immunotherapy meta-analysis safety urothelial cancer this study.

Cystectomy/adverse effects/*methods Humans Laser Therapy/adverse effects/*methods Neoplasm Invasiveness Treatment Outcome Urethra Urinary Bladder Neoplasms/pathology/*surgery Bladder cancer Laser surgery Systematic review and meta-analysis Transurethral resection

Chemotherapy Adjuvant *Cystectomy/methods Humans Neoadjuvant Therapy Smoking/*adverse effects Survival Rate Treatment Outcome Urinary Bladder Neoplasms/drug therapy/*mortality/*surgery cigarette smoking cystectomy recurrence survival urinary bladder neoplasms

Cystectomy/*methods Humans Laparoscopy/*methods Minimally Invasive Surgical Procedures/methods Robotic Surgical Procedures/*methods Treatment Outcome Urinary Bladder Neoplasms/*surgery Urologic Surgical Procedures/*methods

Humans *Mental Health Quality of Life Treatment Outcome Urinary Bladder Neoplasms/*psychology

Cystectomy/adverse effects/*methods Humans *Robotic Surgical Procedures Treatment Outcome Urinary Bladder Neoplasms/*surgery Bladder cancer Cystectomy Meta-analysis Minimally invasive Robotics

Administration Intravesical Drug Therapy/instrumentation Humans Neoplasm Invasiveness Treatment Outcome Urinary Bladder Neoplasms/*drug therapy/pathology Emda Nmibc NMIBC Carcinome de la vessie TURBT EMDA RITE Synergo Rite Synergo Turbt Urothelial carcinoma

Css Os Pfs neoadjuvant chemotherapy outcome primary MIBC secondary MIBC

*Cystectomy/methods *Enhanced Recovery After Surgery Humans Length of Stay Treatment Outcome Urinary Bladder Neoplasms/*surgery Cystectomy Enhanced Recovery After Surgery Enhanced recovery Outcomes

Aged Carcinoma Transitional Cell/*surgery *Cystectomy/methods Female Humans *Lymph Node Excision Male Middle Aged Postoperative Complications Randomized Controlled Trials as Topic Treatment Outcome Urinary Bladder Neoplasms/*surgery

Humans Patient Outcome Assessment *Patient Reported Outcome Measures Quality of Life Randomized Controlled Trials as Topic Reproducibility of Results Urinary Bladder Neoplasms/*diagnosis/pathology/psychology/*therapy Early bladder cancer Non-muscle invasive bladder cancer Patient-reported outcome measures Systematic review

Cystectomy/*methods Humans Postoperative Complications/epidemiology Quality of Life Randomized Controlled Trials as Topic Robotic Surgical Procedures/*methods Treatment Outcome Urinary Bladder Neoplasms/*surgery

Cystectomy/*methods Humans *Quality of Life Randomized Controlled Trials as Topic Treatment Outcome Urinary Bladder Neoplasms/*surgery *Urinary Diversion/methods *Urinary Reservoirs Continent Bladder cancer index Bricker Cystectomie radicale Ileal conduit Meta-analysis Méta-analyse Néovessie de substitution Orthotopic neobladder Quality of life Qualité de vie Radical cystectomy Revue systématique Systematic review

Antibodies Monoclonal/adverse effects/therapeutic use Antibodies Monoclonal Humanized/adverse effects/therapeutic use Antineoplastic Agents Immunological/*therapeutic use B7-H1 Antigen/*antagonists & inhibitors Clinical Trials Phase III as Topic Humans Network Meta-Analysis Programmed Cell Death 1 Receptor/*antagonists & inhibitors Salvage Therapy/*methods Survival Analysis Treatment Outcome Urinary Bladder Neoplasms/*drug therapy/*secondary PD-1 inhibitor PDL-1 inhibitor atezolizumab pembrolizumab urothelial bladder cancer

Blood Loss Surgical/statistics & numerical data Blood Transfusion/statistics & numerical data Cystectomy/*adverse effects/methods Hospital Mortality Humans Length of Stay/statistics & numerical data Operative Time Postoperative Complications/*epidemiology/etiology Quality of Life Risk Factors Robotic Surgical Procedures/*adverse effects Treatment Outcome Urinary Bladder/surgery Urinary Bladder Neoplasms/*surgery Urinary Diversion/*adverse effects/methods health-related quality of life meta-analysis open radical cystectomy postoperative complication robot-assisted radical cystectomy

Cystectomy/methods/*mortality Humans Lymph Node Excision/methods/*mortality Lymph Nodes/surgery Lymphatic Metastasis Pelvis/pathology Postoperative Complications/etiology Prognosis Randomized Controlled Trials as Topic Survival Rate Treatment Outcome Urinary Bladder Neoplasms/*mortality/pathology/*surgery

Cystectomy/*methods Humans Organ Sparing Treatments/*methods Treatment Outcome Urinary Bladder Neoplasms/*surgery Bladder preservation High-grade non-muscle-invasive bladder cancer Meta-analysis Radical cystectomy PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.