*Carcinoma Transitional Cell Evidence-Based Medicine Humans *Radiology Societies Medical United States *Urinary Bladder Neoplasms/diagnostic imaging Auc Appropriate Use Criteria Appropriateness Criteria Bladder cancer Muscle invasive bladder cancer Nonmuscle invasive bladder cancer Surveillance Transitional cell carcinoma Urothelial cancer

Radical cystectomy Vi-rads muscle-invasive bladder cancer urothelial carcinoma

Vi-rads bladder cancer bladder cancer staging inter-reader agreement multiparametric magnetic resonance imaging muscle-invasive bladder cancer

Carcinoma Transitional Cell/pathology/*radiotherapy/*surgery *Cystectomy Humans Neoplasm Invasiveness *Radiotherapy Adjuvant Urinary Bladder Neoplasms/pathology/*radiotherapy/*surgery Cystectomie Cystectomy Local recurrence Muscle-invasive bladder cancer Prognosis Pronostic Radiotherapy Radiothérapie Récidive locale Tumeur de vessie infiltrant le muscle

*Biomarkers Tumor Carcinoma Transitional Cell/*genetics/mortality/pathology *DNA Methylation Humans Neoplasm Invasiveness Prognosis Risk Assessment Survival Rate Urinary Bladder Neoplasms/*genetics/mortality/pathology Biomarkers Dna High-risk non–muscle-invasive bladder cancer Methylation Prognostic markers Systematic review molecular markers

Humans Muscle Skeletal/*pathology Neoplasm Invasiveness ROC Curve Radiography/*methods Research Design Urinary Bladder Neoplasms/*diagnosis Bladder cancer Diagnostic imaging Magnetic resonance imaging

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Chemotherapy Adjuvant *Cystectomy/methods Humans Neoadjuvant Therapy Neoplasm Invasiveness Survival Rate Urinary Bladder Neoplasms/*drug therapy/mortality/pathology/*surgery Muscle-invasive bladder cancer Neoadjuvant chemotherapy Overall survival Radical cystectomy

Humans Patient Outcome Assessment *Patient Reported Outcome Measures Quality of Life Randomized Controlled Trials as Topic Reproducibility of Results Urinary Bladder Neoplasms/*diagnosis/pathology/psychology/*therapy Early bladder cancer Non-muscle invasive bladder cancer Patient-reported outcome measures Systematic review

Cystectomy/*methods Humans Organ Sparing Treatments/*methods Treatment Outcome Urinary Bladder Neoplasms/*surgery Bladder preservation High-grade non-muscle-invasive bladder cancer Meta-analysis Radical cystectomy PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abdominal Muscles/*physiopathology Female *Health Services Needs and Demand Humans Middle Aged Neoplasm Metastasis/*physiopathology Quality of Life/*psychology *Social Support Urinary Bladder Neoplasms/*psychology/*secondary/therapy Bladder cancer Concerns Continent diversion Quality of life Systematic review Unmet supportive care needs

Administration Intravesical Antineoplastic Agents/administration & dosage Combined Modality Therapy Cystectomy/methods Humans Randomized Controlled Trials as Topic Saline Solution/*administration & dosage/adverse effects Therapeutic Irrigation/adverse effects/methods Treatment Outcome Urethra Urinary Bladder Neoplasms/drug therapy/surgery/*therapy Continuous saline bladder irrigation Meta-analysis Non-muscle invasive bladder cancer Randomized controlled trials Transurethral resection of bladder tumors

Female Humans Male Prospective Studies *Quality of Life Urinary Bladder Neoplasms/drug therapy/*psychology/radiotherapy Bladder cancer Chemotherapy Muscle-invasive bladder cancer Quality of life Urothelial cancer PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Biopsy/methods Carcinoma in Situ/*pathology/*therapy Humans Muscle Smooth Neoplasm Invasiveness Urinary Bladder Neoplasms/*pathology/therapy Biopsias aleatorias de vejiga Carcinoma in situ Non-muscle invasive bladder cancer Random bladder biopsies Tumor vesical no-músculo invasivo

Bacille Calmette-Guérin Nmibc gemcitabine intravesical therapy meta-analysis non-muscle invasive bladder cancer

Adjuvants Immunologic/*therapeutic use Administration Intravesical BCG Vaccine/*therapeutic use Carcinoma Transitional Cell/pathology/*therapy Cystoscopy Female Humans Male Multivariate Analysis Muscle Smooth/*pathology Neoplasm Invasiveness Neoplasm Recurrence Local/*epidemiology Proportional Hazards Models Sex Factors Survival Rate Urinary Bladder Neoplasms/pathology/*therapy *Urologic Surgical Procedures Bladder cancer Gender differences Local recurrence Meta-analysis Transurethral resection of bladder tumor

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Cisplatin/administration & dosage Deoxycytidine/administration & dosage/analogs & derivatives Doxorubicin/administration & dosage Humans Methotrexate/administration & dosage Muscle Neoplasms/*drug therapy/pathology Neoplasm Invasiveness Prognosis Survival Rate Urinary Bladder Neoplasms/*drug therapy/pathology Vinblastine/administration & dosage Gemcitabine Bladder cancer and cisplatin chemotherapy doxorubicin/adriamycin gemcitabine and cisplatin methotrexate vinblastine

bacille Calmette-Guérin chemotherapy meta-analysis non-muscle invasive bladder cancer prognosis

Combined Modality Therapy *Cystectomy Disease-Free Survival Humans Muscles/*pathology Neoplasm Invasiveness Publication Bias Urinary Bladder Neoplasms/*pathology/*therapy

bladder cancer chemotherapy cystectomy muscle-invasive systematic review of interest.

Chemoradiotherapy Adjuvant Combined Modality Therapy Cystectomy/*methods Disease-Free Survival Humans Muscles/pathology Neoadjuvant Therapy Neoplasm Invasiveness Treatment Outcome Urinary Bladder Neoplasms/pathology/*therapy Bladder cancer Radical cystectomy Trimodal therapy