Biomarkers Tumor/genetics Carcinoma/genetics Gene Expression/genetics Gene Expression Profiling/methods Gene Expression Regulation Neoplastic/genetics Humans Neoplasm Recurrence Local/genetics Odds Ratio Prognosis RNA Circular/*genetics Survival Analysis Transcriptome/genetics Urinary Bladder/pathology Urinary Bladder Neoplasms/*genetics/metabolism bladder cancer circular RNA meta-analysis

Case-Control Studies Humans *Polymorphism Single Nucleotide Promoter Regions Genetic Urinary Bladder Neoplasms/*genetics Vascular Endothelial Growth Factor A/*genetics Bladder cancer Meta-analysis Polymorphism Vascular endothelial growth factor competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

5 alpha reductase inhibitors androgen deprivation therapy androgen receptor bladder cancer

Adult Aged Aged 80 and over Female Humans Male Middle Aged Urinary Bladder Neoplasms/*radiotherapy Bladder neoplasm Bladder preservation Cis Chemoradiotherapy Radiotherapy T1 Bladder cancer

*Biomarkers Tumor Carcinoma Transitional Cell/*genetics/mortality/pathology *DNA Methylation Humans Neoplasm Invasiveness Prognosis Risk Assessment Survival Rate Urinary Bladder Neoplasms/*genetics/mortality/pathology Biomarkers Dna High-risk non–muscle-invasive bladder cancer Methylation Prognostic markers Systematic review molecular markers

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Chemotherapy Adjuvant *Cystectomy/methods Humans Neoadjuvant Therapy Neoplasm Invasiveness Survival Rate Urinary Bladder Neoplasms/*drug therapy/mortality/pathology/*surgery Muscle-invasive bladder cancer Neoadjuvant chemotherapy Overall survival Radical cystectomy

Arylamine N-Acetyltransferase/*genetics Asian People/genetics Humans *Polymorphism Single Nucleotide Smoking/epidemiology Urinary Bladder Neoplasms/epidemiology/ethnology/*genetics White People/genetics Bladder cancer Meta-analysis N-acetyltransferase 2 Polymorphism competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Biomarkers Tumor/*metabolism Humans RNA Long Noncoding/*metabolism Urinary Bladder Neoplasms/*diagnosis/*genetics/pathology bladder cancer lncRNAs meta-analysis non-invasive diagnosis

*Cystectomy/methods Humans Postoperative Complications/*epidemiology Prognosis Survival Rate Urinary Bladder Neoplasms/*mortality/*surgery Bladder cancer clinical markers morbidity mortality radical cystectomy survival

Metabolic syndrome (MS) bladder cancer (BC) grade meta-analysis stage form (available at http://dx.doi.org/10.21037/tcr-20-3350). The authors have no conflicts of interest to declare.

Biomarkers/urine DNA Mutational Analysis DNA Neoplasm/*urine Disease Progression Humans Mutation Neoplasm Recurrence Local/*diagnosis/genetics/*urine Sensitivity and Specificity Urinary Bladder Neoplasms/*diagnosis/genetics/*urine #BladderCancer #blcsm biomarkers molecular diagnostics urinary bladder neoplasms urine analysis Amsterdam UMC location VUmc. J. Bosschieter R.D.M. Steenbergen and J.A. Nieuwenhuijzen are inventors on patent(s) related to the work.

*Anesthesia Spinal Cystectomy Humans Obturator Nerve Ultrasonography Interventional *Urinary Bladder Neoplasms/surgery

Carcinoma Transitional Cell/diagnosis/epidemiology/*therapy Child Combined Modality Therapy *Disease Management Disease Progression Global Health Humans Incidence Risk Factors Survival Rate/trends Urinary Bladder/*pathology Urinary Bladder Neoplasms/diagnosis/epidemiology/*therapy Management Pediatric Surveillance Transurethral resection Urothelial cell carcinoma

Coloring Agents Humans Indocyanine Green Lymph Node Excision *Lymphatic Metastasis/diagnostic imaging *Lymphography Male Pelvis *Prostatic Neoplasms/diagnostic imaging/pathology Sentinel Lymph Node Biopsy *Urinary Bladder Neoplasms/diagnostic imaging/pathology Cáncer de Próstata Ganglio centinela Linfadenectomía Lymph node dissection Prostate cáncer Sentinel lymph node Verde de Indocianina

Humans Patient Outcome Assessment *Patient Reported Outcome Measures Quality of Life Randomized Controlled Trials as Topic Reproducibility of Results Urinary Bladder Neoplasms/*diagnosis/pathology/psychology/*therapy Early bladder cancer Non-muscle invasive bladder cancer Patient-reported outcome measures Systematic review

Anastomosis Surgical/adverse effects/instrumentation/methods Constriction Pathologic/etiology Cystectomy/*instrumentation/methods Humans Ileum/surgery Incidence Postoperative Complications/etiology Stents/*adverse effects Ureter/surgery Ureteral Obstruction/*etiology Urinary Bladder Neoplasms/surgery Urinary Catheters/adverse effects Urinary Diversion/adverse effects/*instrumentation/methods Cystectomy Internal double-J stent Orthotopic neobladder Ureteroileal anastomosis stricture Urinary diversion

Adult Aged Air Pollution/*adverse effects Carcinogens Environmental/*adverse effects Cohort Studies Environmental Exposure/*adverse effects Europe/epidemiology Female Humans Incidence Male Meta-Analysis as Topic Middle Aged Nitrogen Oxides/adverse effects Particulate Matter/adverse effects Prospective Studies Risk Factors Urinary Bladder Neoplasms/*epidemiology/etiology Air pollution Bladder cancer Environment Prevention

diagnosis meta-analysis urinary bladder urine biomarkers urothelial carcinoma BioScience Corp. Norihiko Masuda Osamu Ogawa Meyeon Park Alvin Y Liu Yunfeng Dai Landon Kozai Hideki Furuya Yair Lotan and Takashi Kobayashi declare that they have no conflicts of interest.

Cystectomy/*methods Humans *Quality of Life Randomized Controlled Trials as Topic Treatment Outcome Urinary Bladder Neoplasms/*surgery *Urinary Diversion/methods *Urinary Reservoirs Continent Bladder cancer index Bricker Cystectomie radicale Ileal conduit Meta-analysis Méta-analyse Néovessie de substitution Orthotopic neobladder Quality of life Qualité de vie Radical cystectomy Revue systématique Systematic review

Adult Aged Aged 80 and over Cystectomy/methods/mortality Female Humans Hydronephrosis/*physiopathology/surgery Male Middle Aged Neoplasm Staging Prognosis Proportional Hazards Models Retrospective Studies Urinary Bladder/pathology Urinary Bladder Neoplasms/*complications/*pathology