Carcinoma Transitional Cell/pathology/*radiotherapy/*surgery *Cystectomy Humans Neoplasm Invasiveness *Radiotherapy Adjuvant Urinary Bladder Neoplasms/pathology/*radiotherapy/*surgery Cystectomie Cystectomy Local recurrence Muscle-invasive bladder cancer Prognosis Pronostic Radiotherapy Radiothérapie Récidive locale Tumeur de vessie infiltrant le muscle

Cystectomy/*adverse effects Female Humans Postoperative Complications/*etiology Urinary Bladder Neoplasms/*surgery Vaginal Diseases/*etiology

Cystectomy/*methods/rehabilitation Humans Robotic Surgical Procedures/*methods Urinary Bladder Neoplasms/*surgery Bladder cancer Laparoscopic Radical cystectomy Robotic assisted

*Biomarkers Tumor Carcinoma Transitional Cell/*genetics/mortality/pathology *DNA Methylation Humans Neoplasm Invasiveness Prognosis Risk Assessment Survival Rate Urinary Bladder Neoplasms/*genetics/mortality/pathology Biomarkers Dna High-risk non–muscle-invasive bladder cancer Methylation Prognostic markers Systematic review molecular markers

Humans Muscle Skeletal/*pathology Neoplasm Invasiveness ROC Curve Radiography/*methods Research Design Urinary Bladder Neoplasms/*diagnosis Bladder cancer Diagnostic imaging Magnetic resonance imaging

Androgen Antagonists/*therapeutic use Humans Male Observational Studies as Topic Prostatic Neoplasms/*drug therapy Risk Assessment Urinary Bladder Neoplasms/epidemiology/*prevention & control Androgen deprivation therapy Bladder cancer Pharmacoepidemiology Prostate cancer Systematic review

Biomarkers Carcinogens/analysis *Electronic Nicotine Delivery Systems Humans *Urinary Bladder Neoplasms/diagnosis/epidemiology/etiology *Vaping Bladder cancer Carcinogens Electronic cigarette Urinary biomarkers

bladder cancer cisplatin dose-dense MVAC gemcitabine neoadjuvant chemotherapy

Biomarkers Tumor/*metabolism Humans RNA Long Noncoding/*metabolism Urinary Bladder Neoplasms/*diagnosis/*genetics/pathology bladder cancer lncRNAs meta-analysis non-invasive diagnosis

*Cystectomy/methods Humans Postoperative Complications/*epidemiology Prognosis Survival Rate Urinary Bladder Neoplasms/*mortality/*surgery Bladder cancer clinical markers morbidity mortality radical cystectomy survival

Bladder cancer blood transfusion cystectomy oncology prognostic marker urothelial carcinoma

Biomarkers/urine DNA Mutational Analysis DNA Neoplasm/*urine Disease Progression Humans Mutation Neoplasm Recurrence Local/*diagnosis/genetics/*urine Sensitivity and Specificity Urinary Bladder Neoplasms/*diagnosis/genetics/*urine #BladderCancer #blcsm biomarkers molecular diagnostics urinary bladder neoplasms urine analysis Amsterdam UMC location VUmc. J. Bosschieter R.D.M. Steenbergen and J.A. Nieuwenhuijzen are inventors on patent(s) related to the work.

Css Os Pfs neoadjuvant chemotherapy outcome primary MIBC secondary MIBC

Aged Carcinoma Transitional Cell/*surgery *Cystectomy/methods Female Humans *Lymph Node Excision Male Middle Aged Postoperative Complications Randomized Controlled Trials as Topic Treatment Outcome Urinary Bladder Neoplasms/*surgery

Anesthetics Local/*therapeutic use *Cystoscopy Humans Lidocaine/*therapeutic use Male Pain Management/*methods Pain Measurement Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/diagnosis/therapy administration cystoscopy intravesical lidocaine pain procedural urinary bladder neoplasms

Carcinoma Transitional Cell/diagnosis/epidemiology/*therapy Child Combined Modality Therapy *Disease Management Disease Progression Global Health Humans Incidence Risk Factors Survival Rate/trends Urinary Bladder/*pathology Urinary Bladder Neoplasms/diagnosis/epidemiology/*therapy Management Pediatric Surveillance Transurethral resection Urothelial cell carcinoma

Coloring Agents Humans Indocyanine Green Lymph Node Excision *Lymphatic Metastasis/diagnostic imaging *Lymphography Male Pelvis *Prostatic Neoplasms/diagnostic imaging/pathology Sentinel Lymph Node Biopsy *Urinary Bladder Neoplasms/diagnostic imaging/pathology Cáncer de Próstata Ganglio centinela Linfadenectomía Lymph node dissection Prostate cáncer Sentinel lymph node Verde de Indocianina

Humans Patient Outcome Assessment *Patient Reported Outcome Measures Quality of Life Randomized Controlled Trials as Topic Reproducibility of Results Urinary Bladder Neoplasms/*diagnosis/pathology/psychology/*therapy Early bladder cancer Non-muscle invasive bladder cancer Patient-reported outcome measures Systematic review

Anastomosis Surgical/adverse effects/instrumentation/methods Constriction Pathologic/etiology Cystectomy/*instrumentation/methods Humans Ileum/surgery Incidence Postoperative Complications/etiology Stents/*adverse effects Ureter/surgery Ureteral Obstruction/*etiology Urinary Bladder Neoplasms/surgery Urinary Catheters/adverse effects Urinary Diversion/adverse effects/*instrumentation/methods Cystectomy Internal double-J stent Orthotopic neobladder Ureteroileal anastomosis stricture Urinary diversion

Anxiety/therapy Cystectomy/*psychology Depression/therapy *Exercise Therapy Humans Physical Fitness Quality of Life Urinary Bladder Neoplasms/*psychology/*surgery Bladder cancer exercise psychosocial interventions radical cystectomy