Biomarkers Tumor/*urine DNA Neoplasm/*urine Humans RNA Neoplasm/*urine Urinary Bladder Neoplasms/*genetics/*urine Watchful Waiting Biomarkers Bladder Genetic Surveillance

Cystectomy/adverse effects/*methods Humans Laser Therapy/adverse effects/*methods Neoplasm Invasiveness Treatment Outcome Urethra Urinary Bladder Neoplasms/pathology/*surgery Bladder cancer Laser surgery Systematic review and meta-analysis Transurethral resection

Antihypertensive Agents/*adverse effects/therapeutic use Disease Susceptibility Dose-Response Relationship Drug Humans Hypertension/complications/drug therapy/etiology Kidney Neoplasms/*epidemiology/*etiology Odds Ratio Publication Bias Risk Assessment Risk Factors Urinary Bladder Neoplasms/*epidemiology/*etiology antihypertensive medications bladder cancer kidney cancer meta-analysis risk interest.

Cystectomy/*methods Humans Neoplasm Invasiveness Urethra Urinary Bladder Neoplasms/pathology/*surgery Bladder tumor En bloc resection Meta-analysis Transurethral resection

Chemotherapy Adjuvant *Cystectomy/methods Humans Neoadjuvant Therapy Smoking/*adverse effects Survival Rate Treatment Outcome Urinary Bladder Neoplasms/drug therapy/*mortality/*surgery cigarette smoking cystectomy recurrence survival urinary bladder neoplasms

Adjuvants Immunologic Cystectomy Humans *Kidney Transplantation/adverse effects Risk Factors *Urinary Bladder Neoplasms/epidemiology Bcg Bladder cancer Cáncer vesical Kidney transplantation Trasplante renal

Biomarkers Tumor/genetics Carcinoma/genetics Gene Expression/genetics Gene Expression Profiling/methods Gene Expression Regulation Neoplastic/genetics Humans Neoplasm Recurrence Local/genetics Odds Ratio Prognosis RNA Circular/*genetics Survival Analysis Transcriptome/genetics Urinary Bladder/pathology Urinary Bladder Neoplasms/*genetics/metabolism bladder cancer circular RNA meta-analysis

Blood Loss Surgical/statistics & numerical data Cystectomy/*methods Humans Length of Stay/statistics & numerical data Lymph Node Excision *Minimally Invasive Surgical Procedures Operative Time Postoperative Complications/epidemiology Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/*surgery Bladder cancer Meta-analysis Minimally invasive Open radical cystectomy Randomized controlled trials

Cystectomy/*methods Female Humans Male Observational Studies as Topic Robotic Surgical Procedures/*methods Urinary Bladder Neoplasms/surgery Urinary Diversion/*methods

Case-Control Studies Humans *Polymorphism Single Nucleotide Promoter Regions Genetic Urinary Bladder Neoplasms/*genetics Vascular Endothelial Growth Factor A/*genetics Bladder cancer Meta-analysis Polymorphism Vascular endothelial growth factor competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Cystectomy/*methods Humans Laparoscopy/*methods Minimally Invasive Surgical Procedures/methods Robotic Surgical Procedures/*methods Treatment Outcome Urinary Bladder Neoplasms/*surgery Urologic Surgical Procedures/*methods

Carcinoma Transitional Cell/pathology/*radiotherapy/*surgery *Cystectomy Humans Neoplasm Invasiveness *Radiotherapy Adjuvant Urinary Bladder Neoplasms/pathology/*radiotherapy/*surgery Cystectomie Cystectomy Local recurrence Muscle-invasive bladder cancer Prognosis Pronostic Radiotherapy Radiothérapie Récidive locale Tumeur de vessie infiltrant le muscle

Cystectomy/*adverse effects Female Humans Postoperative Complications/*etiology Urinary Bladder Neoplasms/*surgery Vaginal Diseases/*etiology

Humans *Mental Health Quality of Life Treatment Outcome Urinary Bladder Neoplasms/*psychology

Cystectomy/adverse effects/*methods Humans *Robotic Surgical Procedures Treatment Outcome Urinary Bladder Neoplasms/*surgery Bladder cancer Cystectomy Meta-analysis Minimally invasive Robotics

Carcinoma Transitional Cell/*surgery *Cystectomy Humans Male Neoplasm Recurrence Local Ureter/*pathology Urethra/*pathology Urethral Neoplasms/*surgery Urinary Bladder Neoplasms/*surgery

Administration Intravesical Drug Therapy/instrumentation Humans Neoplasm Invasiveness Treatment Outcome Urinary Bladder Neoplasms/*drug therapy/pathology Emda Nmibc NMIBC Carcinome de la vessie TURBT EMDA RITE Synergo Rite Synergo Turbt Urothelial carcinoma

Adult Aged Aged 80 and over Female Humans Male Middle Aged Urinary Bladder Neoplasms/*radiotherapy Bladder neoplasm Bladder preservation Cis Chemoradiotherapy Radiotherapy T1 Bladder cancer

Cystectomy/*methods/rehabilitation Humans Robotic Surgical Procedures/*methods Urinary Bladder Neoplasms/*surgery Bladder cancer Laparoscopic Radical cystectomy Robotic assisted

*Biomarkers Tumor Carcinoma Transitional Cell/*genetics/mortality/pathology *DNA Methylation Humans Neoplasm Invasiveness Prognosis Risk Assessment Survival Rate Urinary Bladder Neoplasms/*genetics/mortality/pathology Biomarkers Dna High-risk non–muscle-invasive bladder cancer Methylation Prognostic markers Systematic review molecular markers